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CATH Superfamily 1.10.150.850

Spt6, helix-hairpin-helix domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Spt6, helix-hairpin-helix domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Spt6, helix-hairpin-helix domain

This superfamily entry represents the helix-turn-helix N-terminal domain (HTH) of Spt6 (Suppressor of Ty 6, originally discovered in Saccharomyces cerevisiae), a gene that influences general transcription through manipulation of chromatin structure at upstream promoter elements PMID:21419780.

Residues 933-1002 form two consecutive Helix-hairpin-Helix (HhH) motifs that pack together to form a (HhH)2 domain that resembles known dsDNA binding domains PMID:21419780.

PFAM:PF14635, INTERPRO:IPR032706,DOI:10.1016/j.jmb.2011.03.002

GO Diversity

Unique GO annotations
67 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1393 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 14
Function
Unique EC:
Unique GO: 67
Taxonomy
Unique Species: 1393