PDB Information

PDB6O8I
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
Watterson, S.H., Liu, Q., Beaudoin Bertrand, M., Batt, D.G., Li, L., Pattoli, M.A., Skala, S., Cheng, L., Obermeier, M.T., Moore, R., Yang, Z., Vickery, R., Elzinga, P.A., Discenza, L., D'Arienzo, C., Gillooly, K.M., Taylor, T.L., Pulicicchio, C., Zhang, Y., Heimrich, E., McIntyre, K.W., Ruan, Q., Westhouse, R.A., Catlett, I.M., Zheng, N., Chaudhry, C., Dai, J., Galella, M.A., Tebben, A.J., Pokross, M., Li, J., Zhao, R., Smith, D., Rampulla, R., Allentoff, A., Wallace, M.A., Mathur, A., Salter-Cid, L., Macor, J.E., Carter, P.H., Fura, A., Burke, J.R., Tino, J.A.
J. Med. Chem.
HeaderTransferase/Inhibitor
Released2019-03-11
Resolution1.420
CATH Insert Date07 Apr, 2019

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 07 Apr, 2019 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6o8iA01 08 Apr, 2019 3.30.200.20 Assigned
6o8iA02 08 Apr, 2019 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q06187 BTK_HUMAN Homo sapiens Tyrosine-protein kinase BTK