PDB 6hw7

PDB Links
Overview

PDB Information

PDB	6HW7
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.700
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hw7

PDB 6hw7

6hw7a

PDB Chain 6hw7a

6hw7A

PDB Chain 6hw7A

6hw7b

PDB Chain 6hw7b

6hw7B

PDB Chain 6hw7B

6hw7C

PDB Chain 6hw7C

6hw7D

PDB Chain 6hw7D

6hw7E

PDB Chain 6hw7E

6hw7F

PDB Chain 6hw7F

6hw7G

PDB Chain 6hw7G

6hw7H

PDB Chain 6hw7H

6hw7I

PDB Chain 6hw7I

6hw7J

PDB Chain 6hw7J

6hw7K

PDB Chain 6hw7K

6hw7L

PDB Chain 6hw7L

6hw7M

PDB Chain 6hw7M

6hw7N

PDB Chain 6hw7N

6hw7O

PDB Chain 6hw7O

6hw7P

PDB Chain 6hw7P

6hw7Q

PDB Chain 6hw7Q

6hw7R

PDB Chain 6hw7R

6hw7S

PDB Chain 6hw7S

6hw7T

PDB Chain 6hw7T

6hw7U

PDB Chain 6hw7U

6hw7V

PDB Chain 6hw7V

6hw7W

PDB Chain 6hw7W

6hw7X

PDB Chain 6hw7X

6hw7Y

PDB Chain 6hw7Y

6hw7Z

PDB Chain 6hw7Z

6hw7a00

CATH Domain 6hw7a00

6hw7A00

CATH Domain 6hw7A00

6hw7b00

CATH Domain 6hw7b00

6hw7B00

CATH Domain 6hw7B00

6hw7C00

CATH Domain 6hw7C00

6hw7D00

CATH Domain 6hw7D00

6hw7E00

CATH Domain 6hw7E00

6hw7F00

CATH Domain 6hw7F00

6hw7G00

CATH Domain 6hw7G00

6hw7H00

CATH Domain 6hw7H00

6hw7I00

CATH Domain 6hw7I00

6hw7J00

CATH Domain 6hw7J00

6hw7K00

CATH Domain 6hw7K00

6hw7L00

CATH Domain 6hw7L00

6hw7M00

CATH Domain 6hw7M00

6hw7N00

CATH Domain 6hw7N00

6hw7O00

CATH Domain 6hw7O00

6hw7P00

CATH Domain 6hw7P00

6hw7Q00

CATH Domain 6hw7Q00

6hw7R00

CATH Domain 6hw7R00

6hw7S00

CATH Domain 6hw7S00

6hw7T00

CATH Domain 6hw7T00

6hw7U00

CATH Domain 6hw7U00

6hw7V00

CATH Domain 6hw7V00

6hw7W00

CATH Domain 6hw7W00

6hw7X00

CATH Domain 6hw7X00

6hw7Y00

CATH Domain 6hw7Y00

6hw7Z00

CATH Domain 6hw7Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hw7a00	04 Feb, 2019	3.60.20.10	Assigned
6hw7A00	04 Feb, 2019	3.60.20.10	Assigned
6hw7b00	04 Feb, 2019	3.60.20.10	Assigned
6hw7B00	04 Feb, 2019	3.60.20.10	Assigned
6hw7C00	04 Feb, 2019	3.60.20.10	Assigned
6hw7D00	04 Feb, 2019	3.60.20.10	Assigned
6hw7E00	04 Feb, 2019	3.60.20.10	Assigned
6hw7F00	04 Feb, 2019	3.60.20.10	Assigned
6hw7G00	04 Feb, 2019	3.60.20.10	Assigned
6hw7H00	04 Feb, 2019	3.60.20.10	Assigned
6hw7I00	04 Feb, 2019	3.60.20.10	Assigned
6hw7J00	04 Feb, 2019	3.60.20.10	Assigned
6hw7K00	04 Feb, 2019	3.60.20.10	Assigned
6hw7L00	04 Feb, 2019	3.60.20.10	Assigned
6hw7M00	04 Feb, 2019	3.60.20.10	Assigned
6hw7N00	04 Feb, 2019	3.60.20.10	Assigned
6hw7O00	04 Feb, 2019	3.60.20.10	Assigned
6hw7P00	04 Feb, 2019	3.60.20.10	Assigned
6hw7Q00	04 Feb, 2019	3.60.20.10	Assigned
6hw7R00	04 Feb, 2019	3.60.20.10	Assigned
6hw7S00	04 Feb, 2019	3.60.20.10	Assigned
6hw7T00	04 Feb, 2019	3.60.20.10	Assigned
6hw7U00	04 Feb, 2019	3.60.20.10	Assigned
6hw7V00	04 Feb, 2019	3.60.20.10	Assigned
6hw7W00	04 Feb, 2019	3.60.20.10	Assigned
6hw7X00	04 Feb, 2019	3.60.20.10	Assigned
6hw7Y00	04 Feb, 2019	3.60.20.10	Assigned
6hw7Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5