PDB 6hub

PDB Links
Overview

PDB Information

PDB	6HUB
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-05
Resolution	2.900
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hub

PDB 6hub

6huba

PDB Chain 6huba

6hubA

PDB Chain 6hubA

6hubb

PDB Chain 6hubb

6hubB

PDB Chain 6hubB

6hubC

PDB Chain 6hubC

6hubD

PDB Chain 6hubD

6hubE

PDB Chain 6hubE

6hubF

PDB Chain 6hubF

6hubG

PDB Chain 6hubG

6hubH

PDB Chain 6hubH

6hubI

PDB Chain 6hubI

6hubJ

PDB Chain 6hubJ

6hubK

PDB Chain 6hubK

6hubL

PDB Chain 6hubL

6hubM

PDB Chain 6hubM

6hubN

PDB Chain 6hubN

6hubO

PDB Chain 6hubO

6hubP

PDB Chain 6hubP

6hubQ

PDB Chain 6hubQ

6hubR

PDB Chain 6hubR

6hubS

PDB Chain 6hubS

6hubT

PDB Chain 6hubT

6hubU

PDB Chain 6hubU

6hubV

PDB Chain 6hubV

6hubW

PDB Chain 6hubW

6hubX

PDB Chain 6hubX

6hubY

PDB Chain 6hubY

6hubZ

PDB Chain 6hubZ

6huba00

CATH Domain 6huba00

6hubA00

CATH Domain 6hubA00

6hubb00

CATH Domain 6hubb00

6hubB00

CATH Domain 6hubB00

6hubC00

CATH Domain 6hubC00

6hubD00

CATH Domain 6hubD00

6hubE00

CATH Domain 6hubE00

6hubF00

CATH Domain 6hubF00

6hubG00

CATH Domain 6hubG00

6hubH00

CATH Domain 6hubH00

6hubI00

CATH Domain 6hubI00

6hubJ00

CATH Domain 6hubJ00

6hubK00

CATH Domain 6hubK00

6hubL00

CATH Domain 6hubL00

6hubM00

CATH Domain 6hubM00

6hubN00

CATH Domain 6hubN00

6hubO00

CATH Domain 6hubO00

6hubP00

CATH Domain 6hubP00

6hubQ00

CATH Domain 6hubQ00

6hubR00

CATH Domain 6hubR00

6hubS00

CATH Domain 6hubS00

6hubT00

CATH Domain 6hubT00

6hubU00

CATH Domain 6hubU00

6hubV00

CATH Domain 6hubV00

6hubW00

CATH Domain 6hubW00

6hubX00

CATH Domain 6hubX00

6hubY00

CATH Domain 6hubY00

6hubZ00

CATH Domain 6hubZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6huba00	04 Feb, 2019	3.60.20.10	Assigned
6hubA00	04 Feb, 2019	3.60.20.10	Assigned
6hubb00	04 Feb, 2019	3.60.20.10	Assigned
6hubB00	04 Feb, 2019	3.60.20.10	Assigned
6hubC00	04 Feb, 2019	3.60.20.10	Assigned
6hubD00	04 Feb, 2019	3.60.20.10	Assigned
6hubE00	04 Feb, 2019	3.60.20.10	Assigned
6hubF00	04 Feb, 2019	3.60.20.10	Assigned
6hubG00	04 Feb, 2019	3.60.20.10	Assigned
6hubH00	04 Feb, 2019	3.60.20.10	Assigned
6hubI00	04 Feb, 2019	3.60.20.10	Assigned
6hubJ00	04 Feb, 2019	3.60.20.10	Assigned
6hubK00	04 Feb, 2019	3.60.20.10	Assigned
6hubL00	04 Feb, 2019	3.60.20.10	Assigned
6hubM00	04 Feb, 2019	3.60.20.10	Assigned
6hubN00	04 Feb, 2019	3.60.20.10	Assigned
6hubO00	04 Feb, 2019	3.60.20.10	Assigned
6hubP00	04 Feb, 2019	3.60.20.10	Assigned
6hubQ00	04 Feb, 2019	3.60.20.10	Assigned
6hubR00	04 Feb, 2019	3.60.20.10	Assigned
6hubS00	04 Feb, 2019	3.60.20.10	Assigned
6hubT00	04 Feb, 2019	3.60.20.10	Assigned
6hubU00	04 Feb, 2019	3.60.20.10	Assigned
6hubV00	04 Feb, 2019	3.60.20.10	Assigned
6hubW00	04 Feb, 2019	3.60.20.10	Assigned
6hubX00	04 Feb, 2019	3.60.20.10	Assigned
6hubY00	04 Feb, 2019	3.60.20.10	Assigned
6hubZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4