PDB Information

PDB5JHA
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Bohnacker, T., Prota, A.E., Beaufils, F., Burke, J.E., Melone, A., Inglis, A.J., Rageot, D., Sele, A.M., Cmiljanovic, V., Cmiljanovic, N., Bargsten, K., Aher, A., Akhmanova, A., Diaz, J.F., Fabbro, D., Zvelebil, M., Williams, R.L., Steinmetz, M.O., Wymann, M.P.
Nat Commun
HeaderTransferase
Released2016-04-20
Resolution2.510
CATH Insert Date07 May, 2017

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
5jhaA01 12 May, 2017 3.10.20.90 Assigned
5jhaA02 12 May, 2017 2.60.40.150 Assigned
5jhaA03 12 May, 2017 1.25.40.70 Assigned
5jhaA04 12 May, 2017 3.30.1010.10 Assigned
5jhaA05 12 May, 2017 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform