Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
De Savi, C., Bradbury, R.H., Rabow, A.A., Norman, R.A., De Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R.J., Currie, G.S., Curwen, J.O., Davies, C.D., Donald, C.S., Feron, L.J.L., Gingell, H., Glossop, S.C., Hayter, B.R., Hussain, S., Karoutchi, G., Lamont, S.G., Macfaul, P., Moss, T.A., Pearson, S.E., Tonge, M., Walker, G.E., Weir, H.M., Wilson, Z.
J.Med.Chem.