PDB 4zzx

PDB Information

PDB4ZZX
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
Discovery of 2-[1-(4,4-Difluorocyclohexyl)Piperidin-4-Yl]-6-Fluoro-3-Oxo-2,3-Dihydro-1H-Isoindole-4-Carboxamide (Nms-P118): A Potent, Orally Available and Highly Selective Parp- 1 Inhibitor for Cancer Therapy.
Papeo, G.M.E., Posteri, H., Borghi, D., Busel, A.A., Caprera, F., Casale, E., Ciomei, M., Cirla, A., Corti, E., D'Anello, M., Fasolini, M., Forte, B., Galvani, A., Isacchi, A., Khvat, A., Krasavin, M.Y., Lupi, R., Orsini, P., Perego, R., Pesenti, E., Pezzetta, D., Rainoldi, S., Riccardi-Sirtori, F., Scolaro, A., Sola, F., Zuccotto, F., Felder, E.R., Donati, D., Montagnoli, A.
J.Med.Chem.
HeaderTransferase
Released2015-04-15
Resolution1.650
CATH Insert Date30 Aug, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 31 Aug, 2015 Chopped
B 31 Aug, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4zzxA01 03 Sep, 2015 1.20.142.10 Assigned
4zzxA02 03 Sep, 2015 3.90.228.10 Assigned
4zzxB01 03 Sep, 2015 1.20.142.10 Assigned
4zzxB02 03 Sep, 2015 3.90.228.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q9UGN5 PARP2_HUMAN Homo sapiens Poly [ADP-ribose] polymerase 2
Q9UGN5 PARP2_HUMAN Homo sapiens Poly [ADP-ribose] polymerase 2