PDB 4yfn

PDB Information

PDB4YFN
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli #1/H766
Gene SourceEscherichia coli O139:H28 (strain E24377A / ETEC)
Primary Citation
X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
Molodtsov, V., Fleming, P.R., Eyermann, C.J., Ferguson, A.D., Foulk, M.A., McKinney, D.C., Masse, C.E., Buurman, E.T., Murakami, K.S.
J.Med.Chem.
HeaderTranscription/Transcription Inhibitor
Released2015-02-25
Resolution3.820
CATH Insert Date28 Jun, 2015

PDB Images (30)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Holding pen
D 29 Jun, 2015 Holding pen
E 29 Jun, 2015 Chopped
F 29 Jun, 2015 Chopped
G 29 Jun, 2015 Chopped
H 29 Jun, 2015 Chopped
I 29 Jun, 2015 Holding pen
J 29 Jun, 2015 Holding pen
K 29 Jun, 2015 Chopped
L 29 Jun, 2015 Chopped

CATH Domains (17)

Domain ID Date inserted into CATH Superfamily CATH Status
4yfnA01 22 Jul, 2015 3.30.1360.10 Assigned
4yfnA02 22 Jul, 2015 2.170.120.12 Assigned
4yfnB01 22 Jul, 2016 3.30.1360.10 Assigned
4yfnB02 22 Jul, 2016 2.170.120.12 Assigned
4yfnB03 22 Jul, 2016 1.10.150.20 Assigned
4yfnE00 22 Jul, 2015 3.90.940.10 Assigned
4yfnF01 22 Jul, 2015 1.10.601.10 Assigned
4yfnF02 22 Jul, 2015 1.10.10.10 Assigned
4yfnF03 22 Jul, 2015 1.10.10.10 Assigned
4yfnG01 22 Jul, 2016 3.30.1360.10 Assigned
4yfnG02 22 Jul, 2016 2.170.120.12 Assigned
4yfnH01 22 Jul, 2015 3.30.1360.10 Assigned
4yfnH02 22 Jul, 2015 2.170.120.12 Assigned
4yfnK00 22 Jul, 2015 3.90.940.10 Assigned
4yfnL01 22 Jul, 2015 1.10.601.10 Assigned
4yfnL02 22 Jul, 2015 1.10.10.10 Assigned
4yfnL03 22 Jul, 2015 1.10.10.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
P00579 RPOD_ECOLI Escherichia coli K-12 RNA polymerase sigma factor RpoD
A7ZTK1 RPOZ_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit omega
A7ZTK1 RPOZ_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit omega
A7ZSI4 RPOA_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit alpha
A7ZUK1 RPOB_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit beta
A7ZSI4 RPOA_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit alpha
A7ZUK1 RPOB_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit beta
A7ZUK2 RPOC_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit beta'
P00579 RPOD_ECOLI Escherichia coli K-12 RNA polymerase sigma factor RpoD
A7ZSI4 RPOA_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit alpha
A7ZSI4 RPOA_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit alpha
A7ZUK2 RPOC_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit beta'