PDB 4xaq

PDB Information

PDB4XAQ
MethodX-RAY DIFFRACTION
Host Organismunidentified baculovirus
Gene SourceHomo sapiens
Primary Citation
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures.
Monn, J.A., Prieto, L., Taboada, L., Pedregal, C., Hao, J., Reinhard, M.R., Henry, S.S., Goldsmith, P.J., Beadle, C.D., Walton, L., Man, T., Rudyk, H., Clark, B., Tupper, D., Baker, S.R., Lamas, C., Montero, C., Marcos, A., Blanco, J., Bures, M., Clawson, D.K., Atwell, S., Lu, F., Wang, J., Russell, M., Heinz, B.A., Wang, X., Carter, J.H., Xiang, C., Catlow, J.T., Swanson, S., Sanger, H., Broad, L.M., Johnson, M.P., Knopp, K.L., Simmons, R.M., Johnson, B.G., Shaw, D.B., McKinzie, D.L.
J.Med.Chem.
HeaderSignaling Protein
Released2014-12-15
Resolution2.210
CATH Insert Date28 Jun, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4xaqA01 22 Jul, 2015 3.40.50.2300 Assigned
4xaqA02 22 Jul, 2015 3.40.50.2300 Assigned
4xaqB01 22 Jul, 2015 3.40.50.2300 Assigned
4xaqB02 22 Jul, 2015 3.40.50.2300 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q14416 GRM2_HUMAN Homo sapiens Metabotropic glutamate receptor 2
Q14416 GRM2_HUMAN Homo sapiens Metabotropic glutamate receptor 2