PDB 4wq6

PDB Information

PDB4WQ6
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Zak, M., Liederer, B.M., Sampath, D., Yuen, P.W., Bair, K.W., Baumeister, T., Buckmelter, A.J., Clodfelter, K.H., Cheng, E., Crocker, L., Fu, B., Han, B., Li, G., Ho, Y.C., Lin, J., Liu, X., Ly, J., O'Brien, T., Reynolds, D.J., Skelton, N., Smith, C.C., Tay, S., Wang, W., Wang, Z., Xiao, Y., Zhang, L., Zhao, G., Zheng, X., Dragovich, P.S.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2014-10-21
Resolution1.720
CATH Insert Date28 Jun, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4wq6A01 20 Jul, 2015 Holding pen
4wq6A02 20 Jul, 2015 3.20.20.70 Assigned
4wq6B01 22 Jul, 2015 Holding pen
4wq6B02 22 Jul, 2015 3.20.20.70 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase