PDB 4w1o

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Overview

PDB Information

PDB	4W1O
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis Felding, J., Sorensen, M.D., Poulsen, T.D., Larsen, J., Andersson, C., Refer, P., Engell, K., Ladgefoged, L.G., Thormann, T., Vinggaard, A.M., Hegardt, P., Sohoel, A., Nielse, S.F. J.Med.Chem
Header	Hydrolase
Released	2014-08-14
Resolution	2.200
CATH Insert Date	16 Nov, 2014

PDB Images (9)

Image of CATH 4w1o

4w1o

PDB 4w1o

Image of CATH 4w1oA

4w1oA

PDB Chain 4w1oA

Image of CATH 4w1oB

4w1oB

PDB Chain 4w1oB

Image of CATH 4w1oC

4w1oC

PDB Chain 4w1oC

Image of CATH 4w1oD

4w1oD

PDB Chain 4w1oD

Image of CATH 4w1oA00

4w1oA00

CATH Domain 4w1oA00

Image of CATH 4w1oB00

4w1oB00

CATH Domain 4w1oB00

Image of CATH 4w1oC00

4w1oC00

CATH Domain 4w1oC00

Image of CATH 4w1oD00

4w1oD00

CATH Domain 4w1oD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	17 Nov, 2014	Chopped
B	17 Nov, 2014	Chopped
C	17 Nov, 2014	Chopped
D	17 Nov, 2014	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4w1oA00	19 Nov, 2014	1.10.1300.10	Assigned
4w1oB00	19 Nov, 2014	1.10.1300.10	Assigned
4w1oC00	19 Nov, 2014	1.10.1300.10	Assigned
4w1oD00	19 Nov, 2014	1.10.1300.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D