PDB 4jib

PDB Information

PDB4JIB
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
Plummer, M.S., Cornicelli, J., Roark, H., Skalitzky, D.J., Stankovic, C.J., Bove, S., Pandit, J., Goodman, A., Hicks, J., Shahripour, A., Beidler, D., Lu, X.K., Sanchez, B., Whitehead, C., Sarver, R., Braden, T., Gowan, R., Shen, X.Q., Welch, K., Ogden, A., Sadagopan, N., Baum, H., Miller, H., Banotai, C., Spessard, C., Lightle, S.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2013-03-05
Resolution1.720
CATH Insert Date07 Jul, 2013

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped
B 08 Jul, 2013 Chopped
C 08 Jul, 2013 Chopped
D 08 Jul, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4jibA00 09 Aug, 2013 1.10.1300.10 Assigned
4jibB00 09 Aug, 2013 1.10.1300.10 Assigned
4jibC00 09 Aug, 2013 1.10.1300.10 Assigned
4jibD00 09 Aug, 2013 1.10.1300.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase