PDB 4hy1

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Overview

PDB Information

PDB	4HY1
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Francisella tularensis subsp. holarctica
Primary Citation	Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Tari, L.W., Trzoss, M., Bensen, D.C., Li, X., Chen, Z., Lam, T., Zhang, J., Creighton, C.J., Cunningham, M.L., Kwan, B., Stidham, M., Shaw, K.J., Lightstone, F.C., Wong, S.E., Nguyen, T.B., Nix, J., Finn, J. Bioorg.Med.Chem.Lett.
Header	Isomerase/Isomerase Inhibitor
Released	2012-11-12
Resolution	1.900
CATH Insert Date	28 Mar, 2013

PDB Images (6)

Image of CATH 4hy1

4hy1

PDB 4hy1

Image of CATH 4hy1A

4hy1A

PDB Chain 4hy1A

Image of CATH 4hy1B

4hy1B

PDB Chain 4hy1B

Image of CATH 4hy1A01

4hy1A01

CATH Domain 4hy1A01

Image of CATH 4hy1A02

4hy1A02

CATH Domain 4hy1A02

Image of CATH 4hy1B00

4hy1B00

CATH Domain 4hy1B00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	28 Mar, 2013	Chopped
B	28 Mar, 2013	Chopped

CATH Domains (3)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4hy1A01	17 Apr, 2013	3.30.565.10	Assigned
4hy1A02	17 Apr, 2013	3.30.230.10	Assigned
4hy1B00	14 Jun, 2013	3.30.565.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
A0A0J9WZF0	PARE_FRATH	Francisella tularensis subsp. holarctica LVS	DNA topoisomerase 4 subunit B
A0A0J9WZF0	PARE_FRATH	Francisella tularensis subsp. holarctica LVS	DNA topoisomerase 4 subunit B