PDB 4hfr

PDB Information

PDB4HFR
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11 -Hydroxysteroid Dehydrogenase Type 1 (11 -HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)
Scott, J.S., Bowker, S.S., Deschoolmeester, J., Gerhardt, S., Hargreaves, D., Kilgour, E., Lloyd, A., Mayers, R.M., McCoull, W., Newcombe, N.J., Ogg, D., Packer, M.J., Rees, A., Revill, J., Schofield, P., Selmi, N., Swales, J.G., Whittamore, P.R.
J.Med.Chem.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2012-10-05
Resolution2.730
CATH Insert Date04 Nov, 2012

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped
B 05 Nov, 2012 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4hfrA00 11 Nov, 2012 3.40.50.720 Assigned
4hfrB00 11 Nov, 2012 3.40.50.720 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P28845 DHI1_HUMAN Homo sapiens Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845 DHI1_HUMAN Homo sapiens Corticosteroid 11-beta-dehydrogenase isozyme 1