PDB 4gj7

PDB Information

PDB4GJ7
MethodX-RAY DIFFRACTION
Host OrganismCricetulus griseus
Gene SourceHomo sapiens
Primary Citation
The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches.
Lorthiois, E., Breitenstein, W., Cumin, F., Ehrhardt, C., Francotte, E., Jacoby, E., Ostermann, N., Sellner, H., Kosaka, T., Webb, R.L., Rigel, D.F., Hassiepen, U., Richert, P., Wagner, T., Maibaum, J.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2012-08-09
Resolution2.800
CATH Insert Date28 Mar, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 28 Mar, 2013 Chopped
B 28 Mar, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4gj7A01 04 Nov, 2013 2.40.70.10 Assigned
4gj7A02 04 Nov, 2013 2.40.70.10 Assigned
4gj7B01 04 Nov, 2013 2.40.70.10 Assigned
4gj7B02 04 Nov, 2013 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P00797 RENI_HUMAN Homo sapiens Renin
P00797 RENI_HUMAN Homo sapiens Renin