PDB 4g2j

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Overview

PDB Information

PDB	4G2J
Method	X-RAY DIFFRACTION
Host Organism
Gene Source	Homo sapiens
Primary Citation	Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. Claffey, M.M., Helal, C.J., Verhoest, P.R., Kang, Z., Fors, K.S., Jung, S., Zhong, J., Bundesmann, M.W., Hou, X., Lui, S., Kleiman, R.J., Vanase-Frawley, M., Schmidt, A.W., Menniti, F., Schmidt, C.J., Hoffman, W.E., Hajos, M., McDowell, L., O'Connor, R.E., Macdougall-Murphy, M., Fonseca, K.R., Becker, S.L., Nelson, F.R., Liras, S. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2012-07-12
Resolution	2.400
CATH Insert Date	07 Jul, 2013

PDB Images (5)

Image of CATH 4g2j

4g2j

PDB 4g2j

Image of CATH 4g2jA

4g2jA

PDB Chain 4g2jA

Image of CATH 4g2jB

4g2jB

PDB Chain 4g2jB

Image of CATH 4g2jA00

4g2jA00

CATH Domain 4g2jA00

Image of CATH 4g2jB00

4g2jB00

CATH Domain 4g2jB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	08 Jul, 2013	Chopped
B	08 Jul, 2013	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4g2jA00	09 Aug, 2013	1.10.1300.10	Assigned
4g2jB00	09 Aug, 2013	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O76083	PDE9A_HUMAN	Homo sapiens	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
O76083	PDE9A_HUMAN	Homo sapiens	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A