PDB Information

PDB4EZK
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Sutherlin, D.P., Baker, S., Bisconte, A., Blaney, P.M., Brown, A., Chan, B.K., Chantry, D., Castanedo, G., DePledge, P., Goldsmith, P., Goldstein, D.M., Hancox, T., Kaur, J., Knowles, D., Kondru, R., Lesnick, J., Lucas, M.C., Lewis, C., Murray, J., Nadin, A.J., Nonomiya, J., Pang, J., Pegg, N., Price, S., Reif, K., Safina, B.S., Salphati, L., Staben, S., Seward, E.M., Shuttleworth, S., Sohal, S., Sweeney, Z.K., Ultsch, M., Waszkowycz, B., Wei, B.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2012-05-02
Resolution2.800
CATH Insert Date07 Jul, 2013

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
4ezkA01 04 Sep, 2013 3.10.20.90 Assigned
4ezkA02 04 Sep, 2013 2.60.40.150 Assigned
4ezkA03 04 Sep, 2013 1.25.40.70 Assigned
4ezkA04 04 Sep, 2013 3.30.1010.10 Assigned
4ezkA05 04 Sep, 2013 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform