PDB 3hdz

PDB Information

PDB3HDZ
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Owen, D.R., Walker, J.K., Jon Jacobsen, E., Freskos, J.N., Hughes, R.O., Brown, D.L., Bell, A.S., Brown, D.G., Phillips, C., Mischke, B.V., Molyneaux, J.M., Fobian, Y.M., Heasley, S.E., Moon, J.B., Stallings, W.C., Joseph Rogier, D., Fox, D.N., Palmer, M.J., Ringer, T., Rodriquez-Lens, M., Cubbage, J.W., Blevis-Bal, R.M., Benson, A.G., Acker, B.A., Maddux, T.M., Tollefson, M.B., Bond, B.R., Macinnes, A., Yu, Y.
Bioorg.Med.Chem.Lett.
HeaderHydrolase
Released2009-05-07
Resolution1.800
CATH Insert Date16 Aug, 2009

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 16 Aug, 2009 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
3hdzA00 11 Feb, 2010 1.10.1300.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P27815 PDE4A_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4A
O76074 PDE5A_HUMAN Homo sapiens cGMP-specific 3',5'-cyclic phosphodiesterase