PDB 2xwy

PDB Information

PDB2XWY
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHEPATITIS C VIRUS
Primary Citation
Discovery of (7R)-14-Cyclohexyl-7-{[2-(Dimethylamino)Ethyl] (Methyl)Amino}-7,8-Dihydro-6H-Indolo[1,2-E][1,5] Benzoxazocine -11-Carboxylic Acid (Mk-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus Ns5B Polymerase
Narjes, F., Crescenzi, B., Ferrara, M., Habermann, J., Colarusso, S., Del Rosario Rico Ferreira, M., Stansfield, I., Mackay, A.C., Conte, I., Ercolani, C., Zaramella, S., Palumbi, M.C., Meuleman, P., Leroux-Roels, G., Giuliano, C., Fiore, F., Di Marco, S., Baiocco, P., Koch, U., Migliaccio, G., Altamura, S., Laufer, R., De Francesco, R., Rowley, M.
J.Med.Chem.
HeaderTransferase
Released2010-11-06
Resolution2.530
CATH Insert Date23 Jan, 2011

PDB Images (6)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 24 Jan, 2011 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
2xwyA01 03 Oct, 2013 Holding pen
2xwyA02 03 Oct, 2013 Holding pen
2xwyA03 03 Oct, 2013 3.30.70.270 Assigned
2xwyA04 03 Oct, 2013 Holding pen

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P26663 POLG_HCVBK Hepatitis C virus (isolate BK) Genome polyprotein