PDB Information

PDB2XJG
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]Methanone (at13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design.
Woodhead, A.J., Angove, H., Carr, M.G., Chessari, G., Congreve, M., Coyle, J.E., Cosme, J., Graham, B., Day, P.J., Downham, R., Fazal, L., Feltell, R., Figueroa, E., Frederickson, M., Lewis, J., Mcmenamin, R., Murray, C.W., O'Brien, M.A., Parra, L., Patel, S., Phillips, T., Rees, D.C., Rich, S., Smith, D., Trewartha, G., Vinkovic, M., Williams, B., Woolford, A.J.
J.Med.Chem.
HeaderChaperone
Released2010-07-06
Resolution2.250
CATH Insert Date15 Aug, 2010

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 16 Aug, 2010 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
2xjgA00 25 Aug, 2010 3.30.565.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P07900 HS90A_HUMAN Homo sapiens Heat shock protein HSP 90-alpha