Homologous Superfamily: 3.20.20.70

Representative domain: 2vxnA00

Aldolase class I

Classification Lineage (3.20.20.70)

CATH Code	Level Description	Links
3	Alpha Beta
3.20	Alpha-Beta Barrel
3.20.20	TIM Barrel
3.20.20.70	Aldolase class I	Gene3D

Summary of Non-Redundant Representatives


-	-	-	-	109	201	245	592	2158

Non-Redundant Representatives (109)
Alignments (37)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S35 Family Entries in Homologous Superfamily 3.20.20.70 (109)

CATH code	Representative Domain	Representative Keywords	Number of Domains
3.20.20.70.1	2vxnA00	Triosephosphate isomeraseTriose-phosphate isomerase.Leishmania mexicana	219
3.20.20.70.2	1p1xB00	Deoxyribonucleotide catabolic processMembraneCarbohydrate catabolic processDeoxyribose-phosphate aldolase activityDeoxyribose-phosphate aldolase [EC:4.1.2.4]	8
3.20.20.70.3	3ewwA00	Pyrimidine metabolismUridine 5'-monophosphate synthaseNucleusUMP biosynthetic processOrotidine-5'-phosphate decarboxylase activity	85
3.20.20.70.4	3b4uA00	Dihydrodipicolinate synthase [EC:4.2.1.52]Agrobacterium tumefaciens str. C58Dihydrodipicolinate synthaseLysine biosynthesisMetabolic pathways	2
3.20.20.70.5	2e6fA01	Pyrimidine metabolismDihydroorotate oxidase [EC:1.3.3.1]Trypanosoma cruziMetabolic pathwaysDihydroorotate dehydrogenase	50
3.20.20.70.6	1gvfB00	Galactose metabolismD-tagatose-1,6-bisphosphate aldolase subunit kbaYTagatose 1,6-diphosphate aldolase [EC:4.1.2.40]Tagatose-bisphosphate aldolase.Protein binding	14
3.20.20.70.7	3chvA00	Ruegeria pomeroyiPutative uncharacterized protein	3
3.20.20.70.8	1uasA01	Alpha-galactosidase.Alpha-galactosidaseOryza sativa Japonica Group	32
3.20.20.70.9	1qopA00	Phenylalanine, tyrosine and tryptophan biosynthesisSalmonella enterica subsp. enterica serovar TyphimuriumTryptophan synthase alpha chain [EC:4.2.1.20]Tryptophan synthase.Glycine, serine and threonine metabolism	58
3.20.20.70.10	3daqA00	Dihydrodipicolinate synthase [EC:4.2.1.52]Dihydrodipicolinate synthaseStaphylococcus aureus subsp. aureus MRSA252Dihydrodipicolinate synthase.Lysine biosynthesis	8
3.20.20.70.11	2rfgA00	Dihydrodipicolinate synthase [EC:4.2.1.52]Dihydrodipicolinate synthaseHahella chejuensis KCTC 2396Dihydrodipicolinate synthase.Lysine biosynthesis	64
3.20.20.70.12	2wkjA00	Amino sugar and nucleotide sugar metabolismN-acetylneuraminate lyase [EC:4.1.3.3]N-acetylneuraminate lyase.N-acetylneuraminate lyase activityN-acetylneuraminate catabolic process	62
3.20.20.70.13	3a21B01	Streptomyces avermitilisPutative secreted alpha-galactosidase	6
3.20.20.70.14	1thfD00	Thermotoga maritimaCyclase HisF [EC:4.1.3.-]Imidazole glycerol phosphate synthase subunit hisFHistidine metabolismMetabolic pathways	14
3.20.20.70.15	2nwrA00	2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]3-deoxy-8-phosphooctulonate synthase.2-dehydro-3-deoxyphosphooctonate aldolaseLipopolysaccharide biosynthesisMetabolic pathways	128
3.20.20.70.16	1ujpA00	Thermus thermophilus HB8Phenylalanine, tyrosine and tryptophan biosynthesisTryptophan synthase.Tryptophan synthase alpha chain [EC:4.2.1.20]Glycine, serine and threonine metabolism	28
3.20.20.70.17	1nvmA01	Pseudomonas sp. CF6004-hydroxy-2-oxovalerate aldolase.4-hydroxy-2-oxovalerate aldolase	4
3.20.20.70.18	3gvgA00	Triosephosphate isomerase (TIM) [EC:5.3.1.1]Triosephosphate isomeraseFructose and mannose metabolismMetabolic pathwaysGlycolysis / Gluconeogenesis	34
3.20.20.70.19	3c6cA00	Ralstonia eutropha JMP134Putative uncharacterized protein	1
3.20.20.70.20	2tpsB00	Bacillus subtilisThiamine metabolismThiamine-phosphate diphosphorylase.Thiamine-phosphate pyrophosphorylaseThiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	16
3.20.20.70.21	3lb0A00	3-dehydroquinate dehydratase I [EC:4.2.1.10]Phenylalanine, tyrosine and tryptophan biosynthesisSalmonella enterica subsp. enterica serovar Typhimurium3-dehydroquinate dehydrataseMetabolic pathways	17
3.20.20.70.22	3cwnA00	Transaldolase activityMembraneTransaldolase BEscherichia coli K-12Cytosol	29
3.20.20.70.23	1qwgA00	Phosphosulfolactate synthase.Phosphosulfolactate synthaseMethanocaldococcus jannaschiiPhosphosulfolactate synthase [EC:4.4.1.19]	2
3.20.20.70.24	1w3iA00	2-keto-3-deoxy gluconate aldolaseSulfolobus solfataricus	30
3.20.20.70.25	2zdrA01	Amino sugar and nucleotide sugar metabolismCapsule biosynthesis proteinN-acetylneuraminate synthase [EC:2.5.1.56]Neisseria meningitidisMetabolic pathways	6
3.20.20.70.26	1w5qB00	Porphobilinogen synthase [EC:4.2.1.24]Pseudomonas aeruginosaPorphyrin and chlorophyll metabolismPorphobilinogen synthase.Delta-aminolevulinic acid dehydratase	65
3.20.20.70.27	1q6oB00	3-keto-L-gulonate-6-phosphate decarboxylase ulaDMagnesium ion binding3-dehydro-L-gulonate-6-phosphate decarboxylase activity3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85]3-dehydro-L-gulonate-6-phosphate decarboxylase.	46
3.20.20.70.28	1dvjA00	Pyrimidine metabolismMethanothermobacter thermautotrophicus str. Delta HOrotidine-5'-phosphate decarboxylase.Orotidine 5'-phosphate decarboxylaseOrotidine-5'-phosphate decarboxylase [EC:4.1.1.23]	97
3.20.20.70.29	1vyrA00	Enterobacter cloacaePentaerythritol tetranitrate reductase	53
3.20.20.70.30	3elfA00	Fructose-bisphosphate aldolaseFructose and mannose metabolismFructose-bisphosphate aldolase.Metabolic pathwaysPentose phosphate pathway	9
3.20.20.70.31	2r8wA00	Dihydrodipicolinate synthase [EC:4.2.1.52]Agrobacterium tumefaciens str. C58Dihydrodipicolinate synthaseLysine biosynthesisMetabolic pathways	2
3.20.20.70.32	1rqbA01	Methylmalonyl-CoA carboxytransferase.Propionibacterium freudenreichii subsp. shermaniiMethylmalonyl-CoA carboxyltransferase 5S subunit	6
3.20.20.70.33	3lerC00	Dihydrodipicolinate synthase [EC:4.2.1.52]Dihydrodipicolinate synthaseCampylobacter jejuniDihydrodipicolinate synthase.Metabolic pathways	4
3.20.20.70.34	3clmA00	Transaldolase [EC:2.2.1.2]Pentose phosphate pathwayNeisseria gonorrhoeae FA 1090TransaldolaseMetabolic pathways	1
3.20.20.70.35	1gteB05	Pyrimidine metabolismSus scrofaProtein homodimerization activityDihydropyrimidine dehydrogenase (NADP(+)).Dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]	20
3.20.20.70.36	1vr6A02	Thermotoga maritimaPhenylalanine, tyrosine and tryptophan biosynthesisPhospho-2-dehydro-3-deoxyheptonate aldolase3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]3-deoxy-7-phosphoheptulonate synthase.	12
3.20.20.70.37	1ypfA00	Bacillus anthracisGMP reductase [EC:1.7.1.7]Purine metabolismGMP reductase.GMP reductase	3
3.20.20.70.38	3e96A00	Dihydrodipicolinate synthase [EC:4.2.1.52]Bacillus clausii KSM-K16Dihydrodipicolinate synthaseDihydrodipicolinate synthase.Metabolic pathways	4
3.20.20.70.39	1fcqA00	HyaluronidaseHyaluronoglucosaminidase.Apis mellifera	5
3.20.20.70.40	1vc4A00	Indole-3-glycerol phosphate synthase [EC:4.1.1.48]Phenylalanine, tyrosine and tryptophan biosynthesisIndole-3-glycerol phosphate synthaseMetabolic pathwaysIndole-3-glycerol-phosphate synthase.	2
3.20.20.70.41	3igsB00	Amino sugar and nucleotide sugar metabolismPutative N-acetylmannosamine-6-phosphate 2-epimerase 2Salmonella enterica subsp. enterica serovar TyphimuriumN-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]N-acylglucosamine-6-phosphate 2-epimerase.	2
3.20.20.70.42	2nzlA00	PeroxisomeFatty acid alpha-oxidationGlyoxylate and dicarboxylate metabolismMetabolic pathways(S)-2-hydroxy-acid oxidase [EC:1.1.3.15]	43
3.20.20.70.43	1vhnA01	Thermotoga maritimaPutative uncharacterized protein	1
3.20.20.70.44	1w8sE00	Thermoproteus tenaxFructose-bisphosphate aldolase class 1Fructose-bisphosphate aldolase.	50
3.20.20.70.45	1yxyA00	Amino sugar and nucleotide sugar metabolismPutative N-acetylmannosamine-6-phosphate 2-epimeraseN-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]Streptococcus pyogenes serotype M1N-acylglucosamine-6-phosphate 2-epimerase.	4
3.20.20.70.46	1piiA01	Tryptophan biosynthesis protein trpCFIndole-3-glycerol-phosphate synthase activityPhosphoribosylanthranilate isomerase activityEscherichia coli K-12Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC:4.1.1.48 5.3.1.24]	2
3.20.20.70.47	1ub3A00	Thermus thermophilus HB8Deoxyribose-phosphate aldolase.Deoxyribose-phosphate aldolasePentose phosphate pathwayDeoxyribose-phosphate aldolase [EC:4.1.2.4]	12
3.20.20.70.48	1xm3B00	Thiamine metabolismBacillus subtilisThiazole synthaseLyases.Thiamine biosynthesis ThiG	12
3.20.20.70.49	1rd5A00	Indole-3-glycerol-phosphate lyase [EC:4.1.2.8]Indole-3-glycerol phosphate lyase, chloroplasticTryptophan synthase.Benzoxazinoid biosynthesisZea mays	4
3.20.20.70.50	2qezE03	Listeria monocytogenes serotype 4b str. F2365Ethanolamine ammonia-lyase heavy chainEthanolamine ammonia-lyase.Ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]Glycerophospholipid metabolism	14
3.20.20.70.51	2hmcA00	Dihydrodipicolinate synthase [EC:4.2.1.52]Dihydrodipicolinate synthaseAgrobacterium tumefaciens str. C58Metabolic pathwaysLysine biosynthesis	1
3.20.20.70.52	1of8A00	Identical protein bindingNucleus3-deoxy-7-phosphoheptulonate synthase activityPhospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited3-deoxy-7-phosphoheptulonate synthase.	70
3.20.20.70.53	1p0kA00	Terpenoid backbone biosynthesisBacillus subtilisIsopentenyl-diphosphate delta-isomerase [EC:5.3.3.2]Isopentenyl-diphosphate delta-isomeraseIsopentenyl-diphosphate Delta-isomerase.	4
3.20.20.70.54	2w79A00	Thermotoga maritima1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16]1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase.Histidine metabolism	6
3.20.20.70.55	1p4cA00		7
3.20.20.70.56	2fiqB01	Escherichia coli O157:H7Galactose metabolismTagatose 6-phosphate kinase [EC:2.7.1.144]D-tagatose-1,6-bisphosphate aldolase subunit gatZ	4
3.20.20.70.57	1wbhB00	2-dehydro-3-deoxy-phosphogluconate aldolase activityArginine and proline metabolismMembraneKHG/KDPG aldolase2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.16]	22
3.20.20.70.58	1tqjC00	Ribulose-phosphate 3-epimeraseRibulose-phosphate 3-epimerase.Carbon fixation in photosynthetic organismsMetabolic pathwaysPentose phosphate pathway	10
3.20.20.70.59	2qr6A02	Purine metabolismIMP dehydrogenase / GMP reductase C terminusCorynebacterium glutamicumIMP dehydrogenase [EC:1.1.1.205]Metabolic pathways	1
3.20.20.70.60	3ldvA00	Pyrimidine metabolismVibrio choleraeOrotidine-5'-phosphate decarboxylase.Orotidine 5'-phosphate decarboxylaseOrotidine-5'-phosphate decarboxylase [EC:4.1.1.23]	33
3.20.20.70.61	1jvnA02	Glutamine amidotransferase [EC:2.4.2.-]Histidine biosynthetic processPurine nucleoside monophosphate biosynthetic processHistidine metabolismOxo-acid-lyases.	8
3.20.20.70.62	1a53A00	Indole-3-glycerol phosphate synthase [EC:4.1.1.48]Phenylalanine, tyrosine and tryptophan biosynthesisSulfolobus solfataricusIndole-3-glycerol phosphate synthaseIndole-3-glycerol-phosphate synthase.	9
3.20.20.70.63	1m5wA00	Pyridoxine 5'-phosphate synthase.Pyridoxine 5-phosphate synthase [EC:2.6.99.2]Pyridoxine biosynthetic processPyridoxine 5'-phosphate synthaseMetabolic pathways	48
3.20.20.70.64	2qf7A04	Pyruvate carboxylase subunit A [EC:6.4.1.1]Pyruvate carboxylase.Rhizobium etli CFN 42Citrate cycle (TCA cycle)Pyruvate carboxylase subunit B [EC:6.4.1.1]	9
3.20.20.70.65	1sflB00	3-dehydroquinate dehydratase I [EC:4.2.1.10]Phenylalanine, tyrosine and tryptophan biosynthesisStaphylococcus aureus subsp. aureus MW23-dehydroquinate dehydratase3-dehydroquinate dehydratase.	4
3.20.20.70.66	3f4wA00	Aldehyde-lyases.Pentose and glucuronate interconversionsPutative hexulose 6 phosphate synthaseSalmonella enterica subsp. enterica serovar Typhimurium3-hexulose-6-phosphate synthase [EC:4.1.2.43]	2
3.20.20.70.67	3cu2A00	Pentose and glucuronate interconversionsPentose phosphate pathwayRibulose-phosphate 3-epimerase.Haemophilus somnus 129PTRibulose-5-phosphate 3-epimerase	2
3.20.20.70.68	3bv4A00	Fructose-bisphosphate aldolase AOryctolagus cuniculusFructose-bisphosphate aldolase.	185
3.20.20.70.69	2fliC00	Pentose and glucuronate interconversionsPentose phosphate pathwayRibulose-phosphate 3-epimerase.Ribulose-phosphate 3-epimerase [EC:5.1.3.1]Streptococcus pyogenes serotype M1	18
3.20.20.70.70	3cc1B01	BH1870 proteinBacillus halodurans	2
3.20.20.70.71	1n7kA00	Deoxyribose-phosphate aldolase.Probable deoxyribose-phosphate aldolaseAeropyrum pernixPentose phosphate pathwayDeoxyribose-phosphate aldolase [EC:4.1.2.4]	2
3.20.20.70.72	1xxxB00	Dihydrodipicolinate synthase [EC:4.2.1.52]Dihydrodipicolinate synthaseDihydrodipicolinate synthase.Metabolic pathwaysMycobacterium tuberculosis	8
3.20.20.70.73	2iqtA00	Fructose-bisphosphate aldolase class 1Fructose-bisphosphate aldolase, class I [EC:4.1.2.13]Fructose and mannose metabolismMetabolic pathwaysFructose-bisphosphate aldolase.	1
3.20.20.70.74	1ep3A00	Pyrimidine metabolismDihydroorotate oxidase.Lactococcus lactis subsp. cremoris MG1363Dihydroorotate oxidase [EC:1.3.3.1]Dihydroorotate dehydrogenase B, catalytic subunit	3
3.20.20.70.75	3hq1B01	2-isopropylmalate synthase.2-isopropylmalate synthase [EC:2.3.3.13]Pyruvate metabolism2-isopropylmalate synthaseMycobacterium tuberculosis	10
3.20.20.70.76	2yw3E00	Thermus thermophilus HB84-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolaseArginine and proline metabolismPentose phosphate pathwayPentose and glucuronate interconversions	7
3.20.20.70.77	1xi3A00	Pyrococcus furiosusThiamine metabolismThiamine-phosphate diphosphorylase.Thiamine-phosphate pyrophosphorylaseMetabolic pathways	2
3.20.20.70.78	1vcvA00	Deoxyribose-phosphate aldolase.Pyrobaculum aerophilumProbable deoxyribose-phosphate aldolasePentose phosphate pathwayDeoxyribose-phosphate aldolase [EC:4.1.2.4]	2
3.20.20.70.79	1l6wA00	Fructose-6-phosphate aldolase 1Fructose-6-phosphate aldolase 1 [EC:4.1.2.-]Aldehyde-lyases.Escherichia coli K-12	10
3.20.20.70.80	1d3gA00	Pyrimidine metabolismDihydroorotate dehydrogenase, mitochondrialHomo sapiensDihydroorotate dehydrogenase.Dihydroorotate dehydrogenase [EC:1.3.5.2]	32
3.20.20.70.81	2p10C01	Mll9387 proteinMesorhizobium loti	6
3.20.20.70.82	2oczA00	3-dehydroquinate dehydratase I [EC:4.2.1.10]Phenylalanine, tyrosine and tryptophan biosynthesisStreptococcus pyogenes serotype M13-dehydroquinate dehydrataseMetabolic pathways	1
3.20.20.70.83	1vrdB00	Thermotoga maritimaInosine-5'-monophosphate dehydrogenasePurine metabolismIMP dehydrogenase [EC:1.1.1.205]IMP dehydrogenase.	18
3.20.20.70.84	1vhcF00	Arginine and proline metabolism2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.16]2-dehydro-3-deoxy-phosphogluconate aldolase.Metabolic pathwaysGlyoxylate and dicarboxylate metabolism	6
3.20.20.70.85	1to3A00	Carbon-carbon lyases.Uncharacterized aldolase yihTSalmonella enterica subsp. enterica serovar Typhimurium[EC:4.1.-.-]	1
3.20.20.70.86	2p0oA01	Hypothetical proteinEnterococcus faecalisPutative uncharacterized protein	1
3.20.20.70.87	1wa3D00	Thermotoga maritimaArginine and proline metabolism2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.16]Metabolic pathways	9
3.20.20.70.88	1ofdA02	Nitrogen metabolismGlutamate synthase (ferredoxin) [EC:1.4.7.1]Ferredoxin-dependent glutamate synthase 2Glutamate synthase (ferredoxin).Protein binding	9
3.20.20.70.89	1i4nA00	Thermotoga maritimaIndole-3-glycerol phosphate synthaseIndole-3-glycerol-phosphate synthase.	3
3.20.20.70.90	1nsjA00	Thermotoga maritimaN-(5'-phosphoribosyl)anthranilate isomerasePhenylalanine, tyrosine and tryptophan biosynthesisPhosphoribosylanthranilate isomerase.Phosphoribosylanthranilate isomerase [EC:5.3.1.24]	6
3.20.20.70.91	1me8A00	Inosine-5'-monophosphate dehydrogenaseTritrichomonas foetusIMP dehydrogenase.	19
3.20.20.70.92	1x7fA01	Outer surface proteinBacillus cereus ATCC 14579	1
3.20.20.70.93	3ctlA00	[EC:5.1.3.-]D-allulose-6-phosphate 3-epimeraseAllulose 6-phosphate 3-epimerase activityProtein bindingEscherichia coli K-12	12
3.20.20.70.94	1piiA02	Tryptophan biosynthesis protein trpCFPhosphoribosylanthranilate isomerase activityIndole-3-glycerol-phosphate synthase activityEscherichia coli K-12Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC:4.1.1.48 5.3.1.24]	1
3.20.20.70.95	1wx0A00	Thermus thermophilus HB8Transaldolase [EC:2.2.1.2]Pentose phosphate pathwayProbable transaldolaseMetabolic pathways	30
3.20.20.70.96	1w0mA00	Thermoproteus tenaxTriose-phosphate isomerase.Triosephosphate isomerase	24
3.20.20.70.97	1b3oA00	Purine metabolismInosine-5'-monophosphate dehydrogenase 2IMP dehydrogenase [EC:1.1.1.205]Protein bindingIMP dehydrogenase.	1
3.20.20.70.98	3ceuA00	Bacteroides thetaiotaomicronThiamine phosphate pyrophosphorylase	2
3.20.20.70.99	1o94A01	Methylophilus methylotrophusTrimethylamine dehydrogenase.Trimethylamine dehydrogenase	10
3.20.20.70.100	1ps9A01	2,4-dienoyl-CoA reductase (NADPH).2,4-dienoyl-CoA reductase (NADPH2) [EC:1.3.1.34]Escherichia coli K-122,4-dienoyl-CoA reductase [NADPH]	1
3.20.20.70.101	2i1oA02	Putative uncharacterized protein Ta1145Nicotinate phosphoribosyltransferase [EC:2.4.2.11]Nicotinate and nicotinamide metabolismMetabolic pathwaysThermoplasma acidophilum	10
3.20.20.70.102	1oyaA00	Saccharomyces pastorianusNADPH dehydrogenase 1NADPH dehydrogenase.	7
3.20.20.70.103	1x1oA02	Thermus thermophilus HB8Nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]Nicotinate and nicotinamide metabolismNicotinate-nucleotide pyrophosphorylase [carboxylating]Metabolic pathways	33
3.20.20.70.104	1jr1B00	Cricetulus griseusInosine-5'-monophosphate dehydrogenase 2IMP dehydrogenase.	3
3.20.20.70.105	1r30A00	Biotin synthase activity2 iron, 2 sulfur cluster bindingBiotin synthetase [EC:2.8.1.6]Biotin synthaseBiotin biosynthetic process	2
3.20.20.70.106	2b7nA02	Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]Helicobacter pyloriNicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]Nicotinate and nicotinamide metabolismNicotinate-nucleotide diphosphorylase (carboxylating).	11
3.20.20.70.107	1jcnA00	Inosine-5'-monophosphate dehydrogenase 1Homo sapiensIMP dehydrogenase activityIMP dehydrogenase.	6
3.20.20.70.108	1zfjA00	Inosine-5'-monophosphate dehydrogenasePurine metabolismStreptococcus pyogenesIMP dehydrogenase [EC:1.1.1.205]IMP dehydrogenase.	1
3.20.20.70.109	1ofdA03	Nitrogen metabolismFerredoxin-dependent glutamate synthase 2Glutamate synthase (ferredoxin) [EC:1.4.7.1]Glutamate synthase (ferredoxin).Protein binding	9

Close Structural Clusters (26)
Distant Structural Clusters (11)

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Close Structural Clusters 3.20.20.70 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00003.00020.00020.00070/SSG5/1	1i4nA00	10	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/2	1vhcF00	5	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/3	1zfjA00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/4	1rqbA01	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/5	1o94A01	4	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/6	1p4cA00	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/7	1ujpA00	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/8	1ypfA00	4	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/9	3lb0A00	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/10	1w8sE00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/11	1uasA01	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/12	2zdrA01	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/13	3gvgA00	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/14	1w3iA00	10	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/15	1x1oA02	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/16	1gteB05	4	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/17	1x7fA01	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/18	1xi3A00	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/19	1yxyA00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/20	3bv4A00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/21	3c6cA00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/22	3f4wA00	5	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/23	1gvfB00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/24	1jcnA00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/25	1jvnA02	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSG5/26	1vcvA00	6	FASTA Jalview	FASTA Jalview

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Distant Structural Clusters 3.20.20.70 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00003.00020.00020.00070/SSGA9/1	1fcqA00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/2	1r30A00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/3	3cc1B01	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/4	1w5qB00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/5	1gvfB00	6	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/6	1ypfA00	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/7	1xm3B00	12	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/8	3hq1B01	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/9	2fiqB01	3	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/10	1p0kA00	2	FASTA Jalview	FASTA Jalview
00003.00020.00020.00070/SSGA9/11	3cwnA00	5	FASTA Jalview	FASTA Jalview

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.20.20.70

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Homologous Superfamily: 3.20.20.70

Aldolase class I

Classification Lineage (3.20.20.70)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S35 Family Entries in Homologous Superfamily 3.20.20.70 (109)

What is an Close Structural Cluster?

Close Structural Clusters 3.20.20.70 (< 5Å)

What is a Distant Structural Cluster?

Distant Structural Clusters 3.20.20.70 (< 9Å)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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