CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt Q07599
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q07599
NRAM_I63A3
Influenza A virus (A/duck/Ukraine/1/1963(H3N8))
Neuraminidase

PDB Structure

PDB 4KS1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Kerry, P.S., Mohan, S., Russell, R.J., Bance, N., Niikura, M., Pinto, B.M.
Sci Rep