CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P30405
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P30405
PPIF_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

PDB Structure

PDB 3QYU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.
le Maire, A., Gelin, M., Pochet, S., Hoh, F., Pirocchi, M., Guichou, J.F., Ferrer, J.L., Labesse, G.
Acta Crystallogr.,Sect.D