CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Alkaline phosphatase

Enzyme Information

3.1.3.1
Alkaline phosphatase.
based on mapping to UniProt P05187
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P05187
PPB1_HUMAN
Homo sapiens
Alkaline phosphatase, placental type

PDB Structure

PDB 3MK2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Stec, B., Cheltsov, A., Millan, J.L.
Acta Crystallogr.,Sect.F