CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Disintegrin and metalloproteinase domain-containing protein 17

Enzyme Information

3.4.24.86
ADAM 17 endopeptidase.
based on mapping to UniProt P78536
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.

UniProtKB Entries (1)

P78536
ADA17_HUMAN
Homo sapiens
Disintegrin and metalloproteinase domain-containing protein 17

PDB Structure

PDB 3KME
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
Rosner, K.E., Guo, Z., Orth, P., Shipps, G.W., Belanger, D.B., Chan, T.Y., Curran, P.J., Dai, C., Deng, Y., Girijavallabhan, V.M., Hong, L., Lavey, B.J., Lee, J.F., Li, D., Liu, Z., Popovici-Muller, J., Ting, P.C., Vaccaro, H., Wang, L., Wang, T., Yu, W., Zhou, G., Niu, X., Sun, J., Kozlowski, J.A., Lundell, D.J., Madison, V., McKittrick, B., Piwinski, J.J., Shih, N.Y., Arshad Siddiqui, M., Strickland, C.O.
Bioorg.Med.Chem.Lett.