CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt P05979
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

P05979
PGH1_SHEEP
Ovis aries
Prostaglandin G/H synthase 1

PDB Structure

PDB 3KK6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1.
Rimon, G., Sidhu, R.S., Lauver, D.A., Lee, J.Y., Sharma, N.P., Yuan, C., Frieler, R.A., Trievel, R.C., Lucchesi, B.R., Smith, W.L.
Proc.Natl.Acad.Sci.USA