CATH Domain 3ipyB00

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Deoxycytidine kinase

2.7.1.74

Deoxycytidine kinase.

based on mapping to UniProt P27707

NTP + deoxycytidine = NDP + dCMP.

-!- Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.

DCK_HUMAN

Homo sapiens

Deoxycytidine kinase

PDB	3IPY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Jessop, T.C., Tarver, J.E., Carlsen, M., Xu, A., Healy, J.P., Heim-Riether, A., Fu, Q., Taylor, J.A., Augeri, D.J., Shen, M., Stouch, T.R., Swanson, R.V., Tari, L.W., Hunter, M., Hoffman, I., Keyes, P.E., Yu, X.C., Miranda, M., Liu, Q., Swaffield, J.C., David Kimball, S., Nouraldeen, A., Wilson, A.G., Foushee, A.M., Jhaver, K., Finch, R., Anderson, S., Oravecz, T., Carson, K.G. Bioorg.Med.Chem.Lett.