CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 12

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt Q16790
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

Q16790
CAH9_HUMAN
Homo sapiens
Carbonic anhydrase 9

PDB Structure

PDB 3IAI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
Alterio, V., Hilvo, M., Di Fiore, A., Supuran, C.T., Pan, P., Parkkila, S., Scaloni, A., Pastorek, J., Pastorekova, S., Pedone, C., Scozzafava, A., Monti, S.M., De Simone, G.
Proc.Natl.Acad.Sci.USA