CATH Classification

Domain Context

CATH Clusters

Superfamily Trigger factor, C-terminal domain
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q9WZF8
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q9WZF8
TIG_THEMA
Thermotoga maritima MSB8
Trigger factor

PDB Structure

PDB 3GU0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Promiscuous substrate recognition in folding and assembly activities of the trigger factor chaperone
Martinez-Hackert, E., Hendrickson, W.A.
Cell(Cambridge,Mass.)