CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Ephrin type-A receptor 5

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P29320
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29320
EPHA3_HUMAN
Homo sapiens
Ephrin type-A receptor 3

PDB Structure

PDB 3FY2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases.
Davis, T.L., Walker, J.R., Allali-Hassani, A., Parker, S.A., Turk, B.E., Dhe-Paganon, S.
Febs J.