CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Vitamin K-dependent protein C

Enzyme Information

3.4.21.69
Protein C (activated).
based on mapping to UniProt P04070
Degradation of blood coagulation factors Va and VIIIa.
-!- One of the gamma-carboxyglutamic acid-containing coagulation factors. -!- Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P04070
PROC_HUMAN
Homo sapiens
Vitamin K-dependent protein C

PDB Structure

PDB 3F6U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC).
Schmidt, A.E., Padmanabhan, K., Underwood, M.C., Bode, W., Mather, T., Bajaj, S.P.
J.Biol.Chem.