CATH Classification

Domain Context

CATH Clusters

Superfamily Golgi alpha-mannosidase II
Functional Family

Enzyme Information

2.4.1.-
Hexosyltransferases.
based on mapping to UniProt P04062
3.2.1.104
Steryl-beta-glucosidase.
based on mapping to UniProt P04062
Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.
-!- Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.
3.2.1.45
Glucosylceramidase.
based on mapping to UniProt P04062
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine.
-!- Also acts on glucosylsphingosine (cf. EC 3.2.1.62).

UniProtKB Entries (1)

P04062
GLCM_HUMAN
Homo sapiens
Lysosomal acid glucosylceramidase

PDB Structure

PDB 2V3D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Complexes of N-Butyl- and N-Nonyl-Deoxynojirimycin Bound to Acid Beta-Glucosidase: Insights Into the Mechanism of Chemical Chaperone Action in Gaucher Disease.
Brumshtein, B., Greenblatt, H.M., Butters, T.D., Shaaltiel, Y., Aviezer, D., Silman, I., Futerman, A.H., Sussman, J.L.
J.Biol.Chem.