CATH Domain: 2qxiA02 XML data for domain: 2qxiA02

Molscript image for 2qxiA02
2qxiA02
PDB coordinates for domain 2qxiA02

PDB 2qxi, Chain A, Domain 2

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.40 Beta Barrel
2.40.10 Thrombin, subunit H
2.40.10.10 Trypsin-like serine proteases Gene3D
2.40.10.10.13
2.40.10.10.13.1
2.40.10.10.13.1.1
2.40.10.10.13.1.1.1
2.40.10.10.13.1.1.1.1

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Segment boundaries for domain 2qxiA02

Chopping figure for domain 2qxiA02
DomainStart PDB ResidueStop PDB Residue
2qxiA01 16 27
2qxiA01 121 234
2qxiA02 28 120
2qxiA02 235 246

Structural Neighbourhood (38 entries)

There are 38 matching structural neighberhood comparisons for CATH ID 2.40.10.10.13.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 38 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2wphS02 90.69 Serine-type endopeptidase activityCoagulation factor IX (Christmas factor) [EC:3.4.21.22]Homo sapiensComplement and coagulation cascadesCoagulation factor IX 2.40.10.10 108 32 89 2.07 2.30
2jkhA02 90.63 Serine-type endopeptidase activityPositive regulation of cell migrationProtein bindingComplement and coagulation cascadesHomo sapiens 2.40.10.10 105 26 90 1.55 1.71
1elvA01 90.57 Serine-type endopeptidase activitySystemic lupus erythematosusComplement C1s subcomponentHomo sapiensComplement component 1, s subcomponent [EC:3.4.21.42] 2.40.10.10 98 32 88 1.46 1.64
1ym0A02 90.27 Eisenia fetidaLumbrokinase F238 2.40.10.10 112 28 86 1.29 1.49
3beuA02 90.19 Streptomyces griseusTrypsin 2.40.10.10 99 26 90 1.70 1.87
1nn6A02 90.10 ChymaseChymase [EC:3.4.21.39]Homo sapiensRenin-angiotensin systemInterleukin-1 beta biosynthetic process 2.40.10.10 107 37 89 1.65 1.84
1a7sA02 90.08 AzurocidinPositive regulation of phagocytosisAzurophil granuleMonocyte activationPositive regulation of tumor necrosis factor biosynthetic process 2.40.10.10 105 32 92 1.23 1.33
2hlcA01 90.07 CollagenaseHypoderma lineatum 2.40.10.10 104 25 91 2.28 2.50
1orfA02 90.02 Serine-type endopeptidase activityGranzyme A [EC:3.4.21.78]Protein homodimerization activityNucleusCleavage of lamin 2.40.10.10 105 34 91 1.76 1.93
1gvzA02 89.88 Equus caballusKallikrein-1E2 2.40.10.10 115 41 84 1.59 1.89
1bioA02 89.88 Serine-type endopeptidase activityHomo sapiensComponent factor D [EC:3.4.21.46]Complement and coagulation cascadesComplement factor D 2.40.10.10 106 30 89 1.55 1.73
1q3xA03 89.79 Serine-type endopeptidase activityHomo sapiensMannan-binding lectin serine protease 2Calcium-dependent protein bindingComplement activation, lectin pathway 2.40.10.10 100 27 90 1.67 1.86
1p57B02 89.61 Serine protease hepsinIntegral to plasma membraneHepsin (transmembrane protease, serine 1) [EC:3.4.21.-]Homo sapiens 2.40.10.10 118 34 82 1.27 1.54
2asuB02 89.22 Hepatocyte growth factor-like proteinHomo sapiens 2.40.10.10 103 34 85 1.77 2.07
2anyA02 89.01 Serine-type endopeptidase activityExtracellular spaceCytoplasmPlasminogen activationHomo sapiens 2.40.10.10 111 27 87 1.96 2.24
1fiwA02 87.83 Ovis ariesAcrosinDrug binding 2.40.10.10 120 28 80 2.22 2.75
3govB02 87.46 Serine-type endopeptidase activityCalcium ion bindingProtein homodimerization activityExtracellular spaceProtein binding 2.40.10.10 123 31 79 2.23 2.80
2r0lA02 87.44 Serine-type endopeptidase activityHomo sapiensHepatocyte growth factor activatorProtein bindingProteolysis 2.40.10.10 113 32 84 1.88 2.24
1gj7B02 86.28 Regulation of smooth muscle cell migrationCell surfaceUrokinase-type plasminogen activatorProteolysisExtracellular space 2.40.10.10 118 30 80 1.87 2.32
2aiqA02 85.99 Agkistrodon contortrix contortrixAncrod 2.40.10.10 113 27 85 2.21 2.57
1rrkA02 84.61 Complement factor BComplement bindingHomo sapiensComponent factor B [EC:3.4.21.47]Complement and coagulation cascades 2.40.10.10 117 23 70 2.22 3.17
1p3cA02 84.01 Glutamyl-endopeptidaseBacillus intermedius 2.40.10.10 107 16 86 2.47 2.84
1ky9A01 83.85 Two-component systemSerine-type endopeptidase activityProtease doResponse to temperature stimulusProtein binding 2.40.10.10 88 17 79 2.60 3.27
2pkaA00 83.38 Sus scrofaGlandular kallikrein 2.40.10.10 80 38 64 1.89 2.94
2o8lA02 82.54 Glutamyl endopeptidase [EC:3.4.21.19]Glutamyl endopeptidaseStaphylococcus aureus subsp. aureus Mu50 2.40.10.10 101 15 78 2.47 3.16
1agjA02 82.04 Exfoliative toxin AStaphylococcus aureus 2.40.10.10 108 15 79 2.66 3.34
2z9iC01 81.47 Two-component systemPutative serine protease PepD [EC:3.4.21.-]PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE) (MTB32B)Mycobacterium tuberculosis 2.40.10.10 91 12 69 2.28 3.29
2qf3A01 81.35 Protease degSProtein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12 2.40.10.10 102 14 68 2.97 4.33
1lcyA01 80.84 Serine-type endopeptidase activityHtrA serine peptidase 2 [EC:3.4.21.108]Parkinson's diseaseEndoplasmic reticulum membraneNucleus 2.40.10.10 111 13 68 2.85 4.16
1sotA01 80.25 Escherichia coli O157:H7Protease degSSerine protease DegS [EC:3.4.21.-] 2.40.10.10 118 15 67 2.86 4.22
2h2zA02 79.61 Replicase polyprotein 1aSARS coronavirus 2.40.10.10 85 12 66 3.18 4.79
1lvmA02 78.82 Genome polyproteinTobacco etch virus 2.40.10.10 106 9 73 3.34 4.54
2halA01 78.25 Human hepatitis A virus Hu/Australia/HM175/1976Genome polyprotein 2.40.10.10 109 11 74 3.52 4.74
1l1jA01 77.47 Thermotoga maritimaHeat shock serine protease, periplasmic[EC:3.4.21.-] 2.40.10.10 118 11 60 2.98 4.95
2hntC00 75.28 Serine-type endopeptidase activityFibrinolysisProthrombinSoluble fractionPositive regulation of protein phosphorylation 2.40.10.10 67 29 42 0.85 1.98
2h5cA01 74.61 Lysobacter enzymogenesAlpha-lytic protease 2.40.10.10 85 7 69 3.07 4.42
1befA02 72.47 2.40.10.10 85 3 67 3.17 4.71
1eptA00 72.45 Sus scrofaTrypsin 2.40.10.10 43 39 31 0.66 2.09
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Displaying entries 1 to 38 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2qxiA02
PWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQ
ARLSSMVKKTKWINDTMKKHR
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2qxiA02
PWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQ
ARLSSMVKKTKWINDTMKKHR
BLAST against CATH

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Domain History Events (10)

Domain assigned by auto on 12 Jan 2008 20:33

Assigning to "2.40.10.10" based on similarity with "2qxjA02"

Flow stage update by auto on 12 Jan 2008 20:32

No in_process hits for Domain "2qxiA02" ready to be processed

Update comment by auto on 12 Jan 2008 20:27

Domain "2qxiA02" hits Domain "2qxgA02" (100% over 100%) which is currently in process

Update comment by auto on 12 Jan 2008 20:16

Domain "2qxiA02" hits Domain "2qxhA02" (100% over 100%) which is currently in process

Update comment by auto on 12 Jan 2008 17:19

Domain "2qxiA02" hits Domain "2qxjA02" (100% over 100%) which is currently in process

Flow stage update by auto on 12 Jan 2008 17:05

Domain "2qxiA02" hits Domain "2qxjA02" (100% over 100%) which is currently in process

Flow stage update by auto on 12 Jan 2008 17:05

NW result present for Domain "2qxiA02"

Flow stage update by auto on 12 Jan 2008 08:06

All required files are present for Domain "2qxiA02"

Flow stage update by auto on 11 Jan 2008 11:16

Beginning processing for Domain "2qxiA02"

Insertion by auto on 11 Jan 2008 11:08

Final ChopClose added based on similarity with "2qxhA"