CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.10 | Ribbon |
|
2.10.60 | CD59 |
|
2.10.60.10 | CD59 |
Domain Context
CATH Clusters
| Superfamily | CD59 |
| Functional Family | TGF-beta receptor type-2 |
Enzyme Information
| 2.7.11.30 |
Receptor protein serine/threonine kinase.
based on mapping to UniProt P37173
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| P36897 |
TGFR1_HUMAN
Homo sapiens
TGF-beta receptor type-1
|
PDB Structure
| PDB | 2PJY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
Mol.Cell
|