CATH Domain: 2p8vA00 XML data for domain: 2p8vA00

Molscript image for 2p8vA00
2p8vA00
PDB coordinates for domain 2p8vA00

PDB 2p8v, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.7
2.30.29.30.7.1
2.30.29.30.7.1.1
2.30.29.30.7.1.1.1
2.30.29.30.7.1.1.1.1

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Segment boundaries for domain 2p8vA00

Chopping figure for domain 2p8vA00
DomainStart PDB ResidueStop PDB Residue
2p8vA00 5 121

Structural Neighbourhood (32 entries)

There are 32 matching structural neighberhood comparisons for CATH ID 2.30.29.30.7.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 32 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1ddwA00 95.51 DendriteType 5 metabotropic glutamate receptor bindingRattus norvegicusResponse to cocaineResponse to stress 2.30.29.30 109 84 93 0.64 0.69
1evhA00 89.40 LamellipodiumFocal adhesionSH3 domain bindingStress fiberActin polymerization or depolymerization 2.30.29.30 111 27 91 1.85 2.02
1rrpB00 85.87 E3 SUMO-protein ligase RanBP2Ran GTPase bindingNuclear poreProtein import into nucleusHomo sapiens 2.30.29.30 134 19 80 2.69 3.34
2dn6A00 83.79 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens 2.30.29.30 115 3 86 3.04 3.52
1faoA00 83.17 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 3 79 3.21 4.04
1qqgA01 83.10 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 4 76 2.51 3.26
1u5dA00 82.94 Positive regulation of transcription from RNA polymerase II promoterPlasma membraneT cell receptor signaling pathwayAntigen bindingCytoplasm 2.30.29.30 108 3 82 3.51 4.23
3cxbB00 82.76 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 6 80 3.12 3.88
1ntyA02 82.48 Triple functional domain protein [EC:2.7.11.-]Triple functional domain proteinHomo sapiensProtein serine/threonine kinase activityTransmembrane receptor protein tyrosine phosphatase signaling pathway 2.30.29.30 124 7 80 3.83 4.75
1v89A00 82.33 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 6 84 2.92 3.45
1txdA02 82.18 Rho guanine nucleotide exchange factor 12Homo sapiensRegulation of actin cytoskeletonG-protein-coupled receptor bindingG-protein coupled receptor protein signaling pathway 2.30.29.30 121 5 82 3.19 3.86
1omwA05 82.10 MembraneNegative regulation of the force of heart contraction by chemical signalG-protein coupled receptor kinase activityChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 2.30.29.30 101 12 82 3.18 3.88
1zsqA01 81.84 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 4 75 2.53 3.36
1q67A01 81.48 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding 2.30.29.30 140 12 75 3.05 4.03
1qqgA02 81.45 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 7 83 3.41 4.07
2dhjA00 81.44 Rho GTPase-activating protein 21Homo sapiens 2.30.29.30 125 5 84 4.16 4.95
2i5fA00 81.26 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayActin cytoskeleton reorganizationHemopoietic progenitor cell differentiationRuffle organization 2.30.29.30 92 7 75 2.63 3.50
1btnA00 81.25 Mus musculusSpectrin beta chain, brain 1SMAD protein import into nucleusCuticular platePlasma membrane 2.30.29.30 106 2 76 3.01 3.96
2rgnB02 81.18 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 10 78 2.51 3.18
1t77A01 81.15 Lipopolysaccharide-responsive and beige-like anchor proteinHomo sapiensProtein binding 2.30.29.40 105 6 71 2.74 3.82
1plsA00 80.92 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 7 84 3.54 4.18
1kz7C02 80.92 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 6 77 3.74 4.82
1p5tA00 80.65 Mus musculusRas protein signal transductionDocking protein 1Transmembrane receptor protein tyrosine kinase signaling pathwayTransmembrane receptor protein tyrosine kinase signaling protein activity 2.30.29.30 105 1 81 3.30 4.06
2he7A03 80.64 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 2.30.29.30 95 6 76 2.63 3.42
1mkeA00 80.28 Rattus norvegicusNeural Wiskott-Aldrich syndrome protein 2.30.29.30 144 11 74 3.48 4.68
1ef1A03 80.18 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 5 77 3.22 4.14
1w1hD00 79.68 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]PPAR signaling pathwayPeptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorptionNon-small cell lung cancer 2.30.29.30 137 7 70 2.34 3.34
1v88A00 79.62 Oxysterol-binding protein-related protein 8Homo sapiens 2.30.29.30 130 2 75 3.47 4.60
1dbhA02 79.41 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 5 72 3.40 4.68
1pfjA00 78.92 Positive regulation of transcription from RNA polymerase II promoterGeneral RNA polymerase II transcription factor activityGeneral transcription factor IIH subunit 1Nucleotide excision repairRegulation of cyclin-dependent protein kinase activity 2.30.29.30 108 8 82 3.78 4.61
1xr0B01 78.77 Fibroblast growth factor receptor substrate 2Membrane fractionIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase adaptor activityNeurotrophin signaling pathway 2.30.29.30 91 5 74 2.59 3.48
2coaA01 78.52 Homo sapiensSerine/threonine-protein kinase D2 2.30.29.30 118 4 79 3.63 4.56
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Displaying entries 1 to 32 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2p8vA00
STAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWA
DSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLARE
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2p8vA00
STAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWA
DSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLARE
BLAST against CATH

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Domain History Events (6)

Domain assigned by auto on 03 Dec 2007 22:15

Assigning to "2.30.29.30" based on similarity with "1ddvA00"

Flow stage update by auto on 03 Dec 2007 22:04

No in_process hits for Domain "2p8vA00" ready to be processed

Flow stage update by auto on 03 Dec 2007 22:04

NW result present for Domain "2p8vA00"

Flow stage update by auto on 25 Nov 2007 06:34

All required files are present for Domain "2p8vA00"

Flow stage update by auto on 24 Nov 2007 14:37

Beginning processing for Domain "2p8vA00"

Insertion by auto on 24 Nov 2007 14:04

Final ChopClose added based on similarity with "1ddwA"