CATH Domain: 2p45B00 XML data for domain: 2p45B00

Molscript image for 2p45B00
2p45B00
PDB coordinates for domain 2p45B00

PDB 2p45, Chain B, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.60 Sandwich
2.60.40 Immunoglobulin-like
2.60.40.10 Immunoglobulins Gene3D
2.60.40.10.8
2.60.40.10.8.1
2.60.40.10.8.1.1
2.60.40.10.8.1.1.1
2.60.40.10.8.1.1.1.1

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Segment boundaries for domain 2p45B00

Chopping figure for domain 2p45B00
DomainStart PDB ResidueStop PDB Residue
2p45B00 1 121

Structural Neighbourhood (92 entries)

There are 92 matching structural neighberhood comparisons for CATH ID 2.60.40.10.8.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 92 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1t2jA00 90.68 Homo sapiensSingle chain Fv 2.60.40.10 116 62 95 1.82 1.90
1yc7A00 90.31 2.60.40.10 116 61 97 3.52 3.61
3k3qA00 87.99 2.60.40.10 137 56 84 1.90 2.24
2q8bH01 87.95 2.60.40.10 112 40 92 1.90 2.06
2vxtH01 87.63 2.60.40.10 113 38 93 2.04 2.19
1tvdA00 87.46 Homo sapiensHDV103S1 2.60.40.10 116 24 97 3.38 3.47
3d9aH01 87.34 2.60.40.10 112 41 92 2.09 2.27
2otuA00 87.01 2.60.40.10 115 28 95 4.35 4.55
1mjuH01 86.79 2.60.40.10 115 38 95 2.58 2.70
1ogaD01 86.76 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 109 24 90 3.51 3.88
1ncwH01 86.59 2.60.40.10 119 43 94 2.73 2.87
1kgcE01 86.26 T-cell receptor beta-1 chain C regionHomo sapiensProtein binding 2.60.40.10 112 20 92 2.82 3.06
1mjuL01 86.17 2.60.40.10 113 21 90 3.62 4.00
2ij0C00 86.07 Homo sapiensT cell receptor beta variable 20/OR9-2 2.60.40.10 118 23 94 3.25 3.42
1x9qA01 86.05 2.60.40.10 111 18 87 3.42 3.89
1nezH00 86.01 T-cell surface glycoprotein CD8 alpha chainProtein homodimerization activityHematopoietic cell lineageCD8A antigen, alpha polypeptideT cell receptor signaling pathway 2.60.40.10 120 12 89 3.19 3.58
1lp9E01 85.79 2.60.40.10 113 19 95 4.21 4.40
2ak4D01 85.77 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 114 20 94 3.97 4.19
1ogaE01 85.74 T-cell receptor beta-1 chain C regionHomo sapiensProtein binding 2.60.40.10 111 25 93 2.66 2.86
1hxmA01 85.74 2.60.40.10 121 24 92 4.43 4.79
2nw2A01 85.69 TRA@ proteinHomo sapiens 2.60.40.10 103 18 88 3.14 3.54
1u3hA00 85.53 Mus musculusTRAV14-3 2.60.40.10 110 25 91 3.39 3.71
1oaqL00 85.44 2.60.40.10 110 20 91 3.66 4.01
1kgcD01 85.39 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 111 19 94 4.36 4.60
2ialA01 85.35 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 108 21 91 3.73 4.08
1mfaH01 85.22 2.60.40.10 97 32 79 1.95 2.46
1pewA00 85.15 Ig lambda chain V-VI region SUTHomo sapiens 2.60.40.10 108 24 89 3.55 3.96
2hp4A00 84.95 T-cell surface glycoprotein CD8 alpha chainCD8A antigen, alpha polypeptideHematopoietic cell lineagePrimary immunodeficiencyHomo sapiens 2.60.40.10 112 14 91 3.26 3.57
2aepL01 84.92 2.60.40.10 119 15 88 3.52 3.99
1neuA00 84.58 Rattus norvegicusMyelin protein P0 2.60.40.10 115 13 92 2.47 2.68
1qfoC00 84.21 Mus musculusSialoadhesinProtein binding 2.60.40.10 114 20 91 3.26 3.57
3bp6A00 84.19 Mus musculusExternal side of plasma membraneProgrammed cell death protein 1Programmed cell death protein 1T cell receptor signaling pathway 2.60.40.10 111 17 94 4.28 4.51
1hzhH01 83.48 2.60.40.10 119 31 77 2.58 3.34
1eajB00 83.16 Integral to plasma membraneReceptor activityCoxsackievirus and adenovirus receptorViral myocarditisCoxsackievirus and adenovirus receptor 2.60.40.10 120 14 90 3.74 4.16
1xauA00 83.14 Integral to plasma membraneReceptor activityNegative regulation of B cell proliferationProtein bindingMus musculus 2.60.40.10 104 12 82 3.96 4.79
1fhgA00 83.00 TelokinMeleagris gallopavo 2.60.40.10 102 15 77 3.57 4.60
1f97A01 82.97 Mus musculusEpithelial cell differentiationJunctional adhesion molecule ACell adhesionTight junction 2.60.40.10 102 16 84 3.79 4.49
2cqvA00 82.87 Myosin light chain kinase activityProtein phosphorylationHomo sapiensMyosin light chain kinase, smooth muscle 2.60.40.10 114 12 76 3.61 4.71
2v44A01 82.83 Prion diseasesNeural cell adhesion moleculeNeuron cell-cell adhesionPlasma membraneNeural cell adhesion molecule 2 2.60.40.10 94 15 77 3.11 4.01
1f97A02 82.63 Mus musculusEpithelial cell differentiationJunctional adhesion molecule ACell adhesionTight junction 2.60.40.10 105 17 82 3.94 4.76
2rikA01 82.62 TitinOryctolagus cuniculus 2.60.40.10 96 13 77 3.60 4.64
1smoB00 82.52 Receptor activityTriggering receptor expressed on myeloid cells 1Homo sapiensHumoral immune response 2.60.40.10 110 10 89 3.61 4.03
2rikA02 82.45 TitinOryctolagus cuniculus 2.60.40.10 95 14 76 3.53 4.60
1pkoA00 82.44 Rattus norvegicusMyelin-oligodendrocyte glycoproteinPositive regulation of MyD88-dependent toll-like receptor signaling pathway 2.60.40.10 123 17 85 3.39 3.97
1fo0B00 82.38 2.60.40.10 112 16 93 3.40 3.65
2ny1B01 82.33 Zinc ion bindingMaintenance of protein location in cellT-cell surface glycoprotein CD4Signal transductionT cell receptor signaling pathway 2.60.40.10 98 23 81 2.81 3.43
1ypzF01 82.24 2.60.40.10 123 18 91 3.92 4.30
2qsqB01 82.22 Carcinoembryonic antigen-related cell adhesion molecule 5Integral to plasma membraneHomo sapiensBasolateral plasma membrane 2.60.40.10 108 12 89 3.89 4.34
2g5rA00 82.13 Sialic acid-binding Ig-like lectin 7Sialic acid binding Ig-like lectin 7Receptor activityIntegral to plasma membraneHomo sapiens 2.60.40.10 113 15 89 3.88 4.33
1hkfA00 82.12 Integral to plasma membraneNatural cytotoxicity triggering receptor 2Cellular defense responseNatural killer cell mediated cytotoxicitySignal transduction 2.60.40.10 108 15 89 4.03 4.50
2a38B01 81.89 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 99 13 79 3.55 4.48
2c5dC01 81.85 Integral to plasma membraneTransmembrane receptor protein tyrosine kinase activityHomo sapiensTyrosine-protein kinase receptor UFOSignal transduction 2.60.40.10 104 15 78 2.66 3.39
1cs6A04 81.76 Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2 2.60.40.10 90 22 74 3.66 4.94
1vcaA01 81.68 Vascular cell adhesion protein 1MicrovillusPositive regulation of T cell proliferationHeterophilic cell-cell adhesionFilopodium 2.60.40.10 89 20 74 3.52 4.75
3b43A02 81.52 TitinOryctolagus cuniculus 2.60.40.10 97 13 75 3.67 4.84
1koaA03 81.47 Caenorhabditis elegansProtein ZK617.1b, partially confirmed by transcript evidenceLocomotionReproduction 2.60.40.10 96 14 76 3.41 4.44
2dm2A00 81.42 NucleusHomo sapiensPalladinActin filamentMuscle alpha-actinin binding 2.60.40.10 110 12 79 3.94 4.97
2j8hA01 81.36 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 97 16 78 3.69 4.70
1nkrA01 81.28 Integral to plasma membraneReceptor activityHomo sapiensNatural killer cell inhibitory signaling pathwayImmune response 2.60.40.10 97 10 78 3.58 4.56
1cczA01 81.28 Homo sapiensLymphocyte function-associated antigen 3Protein binding 2.60.40.10 93 15 78 3.40 4.33
3cafA01 81.04 Cell surfacePathways in cancerNucleusPositive regulation of cell proliferationFibroblast growth factor binding 2.60.40.10 96 14 77 3.86 4.98
1uctA01 80.98 Immunoglobulin alpha Fc receptorIntegral to plasma membraneCD89 antigenHomo sapiensImmune response 2.60.40.10 91 9 74 3.16 4.26
2bk8A00 80.87 Structural constituent of muscleCalcium ion bindingTelethonin bindingSarcomere organizationActin filament binding 2.60.40.10 97 13 77 3.64 4.69
2rikA03 80.63 TitinOryctolagus cuniculus 2.60.40.10 92 10 76 3.73 4.86
1g1cA00 80.60 Structural constituent of muscleCalcium ion bindingTelethonin bindingSarcomere organizationActin filament binding 2.60.40.10 98 10 78 3.00 3.82
2ec8A04 80.59 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Extracellular spaceAcute myeloid leukemia 2.60.40.10 100 11 75 3.73 4.92
1ncnA00 80.59 T-lymphocyte activation antigen CD86Positive regulation of cell proliferationHomo sapiensImmune responseProtein binding 2.60.40.10 110 13 88 4.21 4.74
1gl4B00 80.53 Chondrocyte differentiationCardiac muscle tissue developmentCartilage development involved in endochondral bone morphogenesisProtein localizationBrain development 2.60.40.10 89 16 73 3.52 4.80
1waaC00 80.23 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 93 13 73 2.55 3.48
2ec8A01 80.22 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Acute myeloid leukemiaProtein binding 2.60.40.10 92 13 64 2.46 3.80
1l6zA02 79.92 Mus musculusCarcinoembryonic antigen-related cell adhesion molecule 1 2.60.40.10 96 14 75 2.74 3.61
1nkrA02 79.82 Receptor activityIntegral to plasma membraneHomo sapiensImmune responseNatural killer cell inhibitory signaling pathway 2.60.40.10 98 15 75 3.45 4.55
1i1rA01 79.81 Jak-STAT signaling pathwayOncostatin-M receptor complexResponse to cytokine stimulusPositive regulation of osteoblast differentiationPositive regulation of tyrosine phosphorylation of Stat1 protein 2.60.40.10 100 8 76 2.97 3.87
1f3rB02 79.51 2.60.40.10 99 17 68 2.92 4.23
2e9wA01 79.46 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Acute myeloid leukemiaExtracellular space 2.60.40.10 84 14 64 2.61 4.04
2gy5A02 79.28 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 2.60.40.10 90 10 71 2.50 3.49
1p53A01 78.99 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 98 13 75 2.94 3.92
1q0xL02 78.53 Mus musculusIg lambda-1 chain V regionProtein binding 2.60.40.10 100 9 72 3.42 4.72
1cwvA03 78.37 InvasinYersinia pseudotuberculosis 2.60.40.920 102 6 73 3.42 4.67
1nctA00 77.82 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 98 15 77 3.71 4.78
1cfbA01 77.56 Calcium ion bindingNeuron cell-cell adhesionNerve maturationDrosophila melanogasterEpidermal growth factor receptor signaling pathway 2.60.40.10 99 6 75 3.52 4.64
1cwvA02 77.45 InvasinYersinia pseudotuberculosis 2.60.40.920 97 7 73 3.34 4.56
1ej6A05 77.14 Mammalian orthoreovirus 3 DearingOuter capsid protein lambda-2 2.60.40.10 95 11 78 3.89 4.96
1qfhA01 77.11 ThermotaxisPhagocytic cupMembrane fractionPhototaxisProtein homodimerization activity 2.60.40.10 111 7 75 3.58 4.72
1v05A00 76.97 Plasma membraneFilamin-CHomo sapiens 2.60.40.10 96 10 74 3.43 4.63
1t0pB00 76.96 Integral to plasma membraneIntercellular adhesion molecule 3Homo sapiensIntercellular adhesion molecule 3Cell adhesion molecules (CAMs) 2.60.40.10 86 12 71 3.56 4.98
1edqA01 76.73 Chitinase ASerratia marcescens 2.60.40.10 107 6 72 3.31 4.57
2nqcA00 76.68 Plasma membraneFilamin-CHomo sapiens 2.60.40.10 97 9 75 3.55 4.73
3bgaA02 75.24 Galactose metabolismBacteroides thetaiotaomicronBeta-galactosidaseSphingolipid metabolismBeta-galactosidase [EC:3.2.1.23] 2.60.40.320 111 7 78 3.75 4.78
1ujtA00 75.02 LuteolysisPositive regulation of axonogenesisCell surfaceIdentical protein bindingHomophilic cell adhesion 2.60.40.10 120 6 75 3.50 4.67
3cmgA04 74.32 Putative beta-galactosidaseBacteroides fragilis NCTC 9343 2.60.40.1560 87 4 69 3.21 4.60
1akpA00 73.98 Actinomycete ATCC 53650Apokedarcidin 2.60.40.230 114 4 73 3.34 4.56
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Displaying entries 1 to 92 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2p45B00
QVQVESGGGLVQAGGSLRLSCAASGYAYTYIYGWFRQAPGKEREGVAADSGGGGTLYADSVKGRTISRDKGKNTVYLQDS
LKPEDTATYYCAAGGYELRDRTYGQWGQGTQVTVSS
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2p45B00
GSQVQXVESGGGLVQAGGSLRLSCAASGYAYTYIYXGWFRQAPGKEREGVAAXDSGGGGTLYADSVKGRXTISRDKGKNT
VYLQXDSLKPEDTATYYCAAGGYELRDRTYGQWGQGTQVTVSS
BLAST against CATH

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Domain History Events (11)

Domain assigned by auto on 15 Mar 2008 20:26

Assigning to "2.60.40.10" based on similarity with "2p46B00"

Flow stage update by auto on 15 Mar 2008 20:26

No in_process hits for Domain "2p45B00" ready to be processed

Update comment by auto on 15 Mar 2008 20:23

Domain "2p45B00" hits Domain "2p46D00" (95.9349593495935% over 100%) which is currently in process

Update comment by auto on 15 Mar 2008 20:20

Domain "2p45B00" hits Domain "2p44B00" (95.1219512195122% over 100%) which is currently in process

Update comment by auto on 15 Mar 2008 20:14

Domain "2p45B00" hits Domain "2p46B00" (95.9349593495935% over 100%) which is currently in process

Update comment by auto on 15 Mar 2008 14:17

Domain "2p45B00" hits Domain "2p47B00" (95.9349593495935% over 100%) which is currently in process

Flow stage update by auto on 15 Mar 2008 14:05

Domain "2p45B00" hits Domain "2p47B00" (95.9349593495935% over 100%) which is currently in process

Flow stage update by auto on 15 Mar 2008 14:05

NW result present for Domain "2p45B00"

Flow stage update by auto on 15 Mar 2008 08:07

All required files are present for Domain "2p45B00"

Flow stage update by auto on 14 Mar 2008 08:23

Beginning processing for Domain "2p45B00"

Insertion by auto on 14 Mar 2008 08:14

Final ChopClose added based on similarity with "2p49B"