CATH Domain: 2obpA00

2obpA00

PDB 2obp, Chain A, Domain 0

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.10	Arc Repressor Mutant, subunit A
1.10.10.10	"winged helix" repressor DNA binding domain	Gene3D
1.10.10.10.8
1.10.10.10.8.1
1.10.10.10.8.1.1
1.10.10.10.8.1.1.1
1.10.10.10.8.1.1.1.1

Structure
Sequence
History

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Segment boundaries for domain 2obpA00

Domain	Start PDB Residue	Stop PDB Residue
2obpA00	12	92

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (113 entries)

There are 113 matching structural neighberhood comparisons for CATH ID 1.10.10.10.8.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
2qvoA00	87.89	Archaeoglobus fulgidusUncharacterized protein AF_1382	1.10.10.10	87	15	87	2.15	2.46
2g7uA01	87.54	Rhodococcus opacusPutative regulator of catechol degradative operon	1.10.10.10	74	21	87	3.38	3.88
2p8tA01	87.43	Pyrococcus horikoshiiPutative uncharacterized protein PH0730	1.10.10.10	75	18	83	2.44	2.94
2dtrA01	87.40	DtxR family transcriptional regulator, Mn-dependent transcriptional regulatorDiphtheria toxin repressorCorynebacterium diphtheriae	1.10.10.10	71	18	89	2.71	3.02
1lvaA01	87.00	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1.10.10.10	59	18	75	1.91	2.54
1on2A01	86.66	Bacillus subtilisTranscriptional regulator mntR	1.10.10.10	72	13	90	3.34	3.67
2qm3A01	86.62	Pyrococcus furiosusPutative uncharacterized protein	1.10.10.10	81	15	79	2.46	3.11
1qbjC00	86.40	CytoplasmNucleolusHomo sapiensDouble-stranded RNA-specific adenosine deaminaseBase conversion or substitution editing	1.10.10.10	66	16	81	2.52	3.08
2gauA02	86.23	Transcriptional regulator, Crp/Fnr familyPorphyromonas gingivalis	1.10.10.10	81	7	83	2.38	2.83
1z05A01	86.05	Vibrio choleraeTranscriptional regulator, ROK family	1.10.10.10	72	12	79	3.24	4.09
1ft9A02	85.95	Rhodospirillum rubrumCooA protein	1.10.10.10	79	10	87	2.44	2.79
1in4A02	85.93	Holliday junction DNA helicase RuvBThermotoga maritimaHomologous recombinationHolliday junction ATP-dependent DNA helicase ruvB	1.10.10.10	73	16	90	3.57	3.93
1sfuA00	85.92	Yaba-like disease virus34L protein	1.10.10.10	70	8	84	2.65	3.14
1w1wE00	85.75	Nuclear mitotic cohesin complexProtein acetylationChromatin bindingCohesin complex subunit SCC1Establishment of mitotic sister chromatid cohesion	1.10.10.580	70	12	84	1.92	2.27
2heoA00	85.43	Mus musculusLeft-handed Z-DNA bindingZ-DNA-binding protein 1	1.10.10.10	59	22	74	2.06	2.78
1lvaA03	85.39	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1.10.10.10	62	16	74	2.01	2.72
2hr3D02	85.18	Probable transcriptional regulatorPseudomonas aeruginosa	1.10.10.10	61	21	77	2.84	3.64
1yg2A01	85.09	Vibrio cholerae pathogenic cycleVibrio choleraePadR family transcriptional regulator, regulatory protein AphAPutative uncharacterized protein	1.10.10.10	79	19	81	2.63	3.25
2jt1A00	85.07	PefI proteinSalmonella enterica subsp. enterica serovar Typhimurium	1.10.10.10	71	19	85	2.17	2.53
2pg4A00	85.02	Aeropyrum pernixPutative uncharacterized protein	1.10.10.10	90	23	84	2.84	3.36
3bz6A01	84.98	Hypothetical proteinPseudomonas syringae pv. tomatoUPF0502 protein PSPTO_2686	1.10.10.10	88	15	79	3.10	3.90
1r1uB00	84.96	CzrA proteinStaphylococcus aureus	1.10.10.10	93	16	76	2.67	3.50
1hw5A02	84.82	TranscriptionTranscription activator activityTranscription repressor activityCRP/FNR family transcriptional regulator, cyclic AMP receptor proteinCatabolite gene activator	1.10.10.10	68	10	74	1.85	2.50
3ctaA01	84.79	Riboflavin metabolismRiboflavin kinaseRiboflavin kinase, archaea type [EC:2.7.1.161]Thermoplasma acidophilum	1.10.10.10	84	14	88	3.15	3.58
1t6sB02	84.65	Chlorobaculum tepidumSegregation and condensation protein BSegregation and condensation protein B	1.10.10.10	77	16	87	3.25	3.74
2ia2C01	84.62	Rhodococcus sp. DK17PcaR	1.10.10.10	60	18	74	2.42	3.27
1ub9A00	84.60	Pyrococcus horikoshiiPutative uncharacterized protein PH1061	1.10.10.10	100	16	72	2.64	3.67
2ia2D01	84.52	Rhodococcus sp. DK17PcaR	1.10.10.10	57	19	67	1.90	2.81
1s3jA02	84.46	Bacillus subtilisUncharacterized HTH-type transcriptional regulator yusO	1.10.10.10	62	25	75	2.75	3.65
1tbxB00	84.42	Sulfolobus virus 1Protein F-93	1.10.10.10	89	15	80	3.22	3.98
1jhfA02	84.24	Repressor LexA [EC:3.4.21.88]TranscriptionDNA bindingLexA repressorTranscription repressor activity	1.10.10.10	69	15	84	3.27	3.87
1hw1A01	83.85	Fatty acid metabolism regulator proteinGntR family transcriptional regulator, negative regulator for fad regulon and positive regulator of fabAEscherichia coli K-12	1.10.10.10	75	10	89	4.20	4.69
1ldjA06	83.84	Cullin-1Cell cycle arrestInduction of apoptosis by intracellular signalsUbiquitin mediated proteolysisWnt signaling pathway	1.10.10.10	68	16	74	2.67	3.61
1ulyA01	83.83	Pyrococcus horikoshiiPutative uncharacterized protein PH1932	1.10.10.10	86	11	76	3.31	4.31
2hztC00	83.77	Bacillus subtilisUncharacterized HTH-type transcriptional regulator ytcD	1.10.10.10	88	12	77	2.82	3.65
1mkmB01	83.76	Thermotoga maritimaTranscriptional regulator, IclR family	1.10.10.10	76	10	85	3.83	4.47
3b73A00	83.46	PhiH1 repressor-likeHaloarcula marismortui	1.10.10.10	86	19	80	3.29	4.10
3jthB00	83.43	Transcription activator HlyUVibrio vulnificus	1.10.10.10	88	18	79	3.06	3.85
1dpuA00	83.39	DNA-dependent DNA replicationReplication protein A 32 kDa subunitNucleotide excision repairDNA replicationReplication factor A2	1.10.10.10	69	14	83	3.60	4.33
1j5yA01	83.30	Thermotoga maritimaTranscriptional regulator, biotin repressor family	1.10.10.10	64	14	77	2.68	3.44
3cuqA02	83.15	ESCRT-II complex subunit VPS22Transcription factor bindingRegulation of transcription from RNA polymerase II promoterHomo sapiensVacuolar-sorting protein SNF8	1.10.10.10	81	10	80	3.16	3.94
1cf7A00	83.15	Protein domain specific bindingTranscription factor bindingE2F transcription factor 4/5Transcription factor E2F4TGF-beta signaling pathway	1.10.10.10	67	11	76	2.72	3.55
2fnaA03	83.12	Sulfolobus solfataricusPutative uncharacterized protein	1.10.10.10	72	8	79	2.63	3.32
1p6rA00	83.04	Bacillus licheniformisPenicillinase repressor	1.10.10.10	82	11	81	3.34	4.09
1o57A01	82.98	Pur operon repressorBacillus subtilisPurine operon repressor	1.10.10.10	72	11	79	3.12	3.94
2f2eA01	82.84	Pseudomonas aeruginosaPutative uncharacterized protein	1.10.10.10	89	20	76	3.35	4.38
2dt5B01	82.84	Thermus thermophilus HB8Redox-sensing transcriptional repressor rexAT-rich DNA-binding protein	1.10.10.10	73	12	81	3.49	4.27
1q1hA00	82.83	Sulfolobus solfataricusTranscription initiation factor TFIIE alpha subunitTranscription factor EBasal transcription factors	1.10.10.10	85	14	77	2.99	3.85
2ns0A00	82.68	Rhodococcus jostii RHA1Putative uncharacterized protein	1.10.10.10	82	12	79	3.41	4.30
1bjaA00	82.60	Transcription regulatory protein motAEnterobacteria phage T4	1.10.10.10	95	10	71	2.55	3.56
1r1tA00	82.59	Transcriptional repressor smtBSynechococcus elongatus PCC 7942	1.10.10.10	98	15	72	3.13	4.32
1ku9A01	82.52	DNA-binding protein MJ1563Methanocaldococcus jannaschii	1.10.10.10	83	10	72	2.79	3.86
3df8A00	82.24	Thermoplasma volcanium GSS1Putative uncharacterized protein TVG1336486	1.10.10.10	94	14	69	2.67	3.86
2fswA00	82.05	Porphyromonas gingivalisPutative uncharacterized protein	1.10.10.10	99	12	70	2.56	3.62
3f6oB00	81.91	Rhodococcus jostii RHA1Probable transcriptional regulator, ArsR family protein	1.10.10.10	91	14	78	3.89	4.99
1lvaA04	81.86	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1.10.10.10	60	13	74	2.91	3.93
3h92A00	81.78	Methanocaldococcus jannaschiiUncharacterized ATP-binding protein MJECL15	1.10.10.10	85	12	69	2.97	4.28
2hoeA01	81.66	Thermotoga maritimaTranscriptional regulator, XylR-related	1.10.10.10	57	12	68	2.94	4.27
2o0yB01	81.65	Rhodococcus jostii RHA1Transcriptional regulator	1.10.10.10	64	20	81	2.89	3.53
1yyvB00	81.32	Putative transcriptional regulatorSalmonella enterica subsp. enterica serovar Typhimurium	1.10.10.10	107	18	63	2.56	4.03
2o0yC01	81.12	Rhodococcus jostii RHA1Transcriptional regulator	1.10.10.10	73	16	79	3.37	4.25
1lddA00	81.02	Mitotic sister chromatid segregationProtein ubiquitinationCyclin catabolic processMeiosis - yeastAnaphase-promoting complex subunit 2	1.10.10.10	74	12	77	3.05	3.91
2hgcA00	80.86	Bacillus subtilisUncharacterized protein yjcQ	1.10.10.10	78	11	84	3.40	4.02
2dbbB01	80.85	Pyrococcus horikoshiiUncharacterized HTH-type transcriptional regulator PH0061	1.10.10.10	55	12	66	3.06	4.62
1xb4B02	80.83	Protein targeting to vacuoleESCRT-II complex subunit VPS25Saccharomyces cerevisiaeESCRT II complexVacuolar protein-sorting-associated protein 25	1.10.10.10	75	14	81	3.25	3.97
1u5tB02	80.79	Protein targeting to vacuoleVacuolar protein-sorting-associated protein 36Protein retention in Golgi apparatusUbiquitin bindingEndocytosis	1.10.10.10	69	8	77	3.21	4.12
1d8jA00	80.51	Basal transcription factorsTranscription initiation factor IIE subunit betaTranscription initiation factor TFIIE beta subunitHomo sapiensProtein binding	1.10.10.10	81	10	82	3.90	4.71
1hstA00	80.48	Histone H1/5Gallus gallusHistone H5	1.10.10.10	74	13	81	3.45	4.22
3elkB00	80.15	Putative uncharacterized protein Ta0346Thermoplasma acidophilum	1.10.10.10	98	11	67	3.06	4.54
3i53B01	80.07	O-methyltransferaseStreptomyces carzinostaticus subsp. neocarzinostaticus	1.10.10.10	91	22	74	3.60	4.82
1lvaA02	79.86	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1.10.10.10	69	10	79	3.53	4.46
3cloA02	79.78	Bacteroides thetaiotaomicronTranscriptional regulator	1.10.10.10	63	14	76	3.35	4.37
1hsjA03	79.67	Staphylococcus aureus subsp. aureus NCTC 8325HTH-type transcriptional regulator sarR	1.10.10.10	82	11	60	2.24	3.67
2jtvA00	79.41	Rhodopseudomonas palustrisPutative uncharacterized protein	1.10.10.10	65	15	80	3.29	4.09
1p4xA02	79.40	Staphylococcus aureus subsp. aureus NCTC 8325HTH-type transcriptional regulator sarS	1.10.10.10	123	11	60	2.38	3.96
1fnnB03	79.33	Pyrobaculum aerophilumCell division control protein 6 (Cdc6), putativeArchaeal cell division control protein 6	1.10.10.10	103	14	69	3.01	4.31
1t56A01	79.30	TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHRMycobacterium tuberculosis	1.10.10.60	46	15	57	2.47	4.32
2r3sB01	79.27		1.10.10.10	76	13	71	2.83	3.96
2hs5A01	79.19	Rhodococcus jostii RHA1Probable transcriptional regulator, GntR family protein	1.10.10.10	67	8	79	3.82	4.82
2fokA02	79.02	Planomicrobium okeanokoitesType-2 restriction enzyme FokI	1.10.10.10	82	10	84	2.83	3.36
2fbiA00	78.97	Probable transcriptional regulatorPseudomonas aeruginosa	1.10.10.10	136	20	52	2.30	4.34
1fp2A01	78.64	Medicago sativaIsoflavone-7-O-methyltransferase 8	1.10.10.10	96	15	68	2.93	4.26
3bwgB01	78.53	GntR family transcriptional regulator, transcriptional regulator of bglABacillus subtilisUncharacterized HTH-type transcriptional regulator yydK	1.10.10.10	68	8	84	3.79	4.49
3cjnA00	78.51	Ruegeria pomeroyiTranscriptional regulator, MarR family	1.10.10.10	139	24	51	2.23	4.37
2nnnC00	78.49	Probable transcriptional regulatorPseudomonas aeruginosa	1.10.10.10	131	20	54	2.63	4.79
2esnA01	78.20	Probable transcriptional regulatorPseudomonas aeruginosa	1.10.10.10	89	12	76	3.76	4.92
2eshA00	78.18	Thermotoga maritimaPutative uncharacterized protein	1.10.10.10	114	19	62	2.81	4.51
2id3A01	78.11	Putative transcriptional regulatorStreptomyces coelicolor	1.10.10.60	47	23	58	2.86	4.89
1biaA01	78.09	Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity	1.10.10.10	64	12	77	3.04	3.90
2fq4A01	78.06	Transcriptional regulator, TetR familyBacillus cereus ATCC 14579	1.10.10.60	47	19	58	2.83	4.84
1p4xA01	77.97	Staphylococcus aureus subsp. aureus NCTC 8325HTH-type transcriptional regulator sarS	1.10.10.10	127	14	58	2.31	3.96
1xd7A00	77.87	Bacillus subtilisPutative HTH-type transcriptional regulator ywnA	1.10.10.10	116	16	60	3.00	4.97
1opcA00	77.70	Two-component systemTwo-component system, OmpR family, phosphate regulon response regulator OmpRTranscriptional regulatory protein ompRProtein bindingEscherichia coli K-12	1.10.10.10	99	11	61	2.67	4.33
3bqzA01	77.67	HTH-type transcriptional regulator qacRStaphylococcus aureus subsp. aureus Mu50	1.10.10.60	49	16	61	3.01	4.93
3dfgA01	77.55	Xanthomonas campestris pv. campestrisRegulatory proteinRegulatory protein recX	1.10.10.10	48	12	55	2.60	4.66
3bddD00	77.50	Streptococcus suis 89/1591Transcriptional regulator, MarR family	1.10.10.10	128	12	50	2.48	4.88
1ldjA07	77.49	Cullin-1Cell cycle arrestInduction of apoptosis by intracellular signalsUbiquitin mediated proteolysisWnt signaling pathway	1.10.10.10	105	5	57	2.80	4.90
1kgsA02	77.48	Thermotoga maritimaResponse regulatorTwo-component system, OmpR family, response regulator	1.10.10.10	97	10	61	2.87	4.64
1cf7B00	77.44	Protein domain specific bindingTranscription factor Dp-2Transcription cofactor activityHomo sapiens	1.10.10.10	82	9	73	3.64	4.97
2gtgA00	77.39	Proactivator polypeptideLipid transportGlycosphingolipid metabolic processEnzyme activator activityIntegral to membrane	1.10.225.10	78	7	82	3.88	4.73
3fm5A00	76.87	Rhodococcus jostii RHA1Transcriptional regulator	1.10.10.10	124	18	52	2.54	4.85
2ijlB00	76.87	Agrobacterium tumefaciens str. C58Molybdenum-binding transcriptional repressorMolybdate transport system regulatory protein	1.10.10.10	103	15	61	2.79	4.56
3cdhA00	76.80	Ruegeria pomeroyiTranscriptional regulator, MarR family	1.10.10.10	129	27	51	2.55	4.98
1bbyA00	76.64	Basal transcription factorsGeneral transcription factor IIF subunit 2General RNA polymerase II transcription factor activityHomo sapiensTranscription initiation factor TFIIF beta subunit	1.10.10.10	69	5	79	3.89	4.91
1p2fA02	76.46	Thermotoga maritimaResponse regulatorTwo-component system, OmpR family, response regulator	1.10.10.10	94	10	62	2.99	4.76
2hyjA01	76.36	Streptomyces coelicolorPutative tetR-family transcriptional regulator	1.10.10.60	46	13	55	2.45	4.39
1lj9B00	76.13	Enterococcus faecalisTranscriptional regulator, MarR family	1.10.10.10	142	15	50	2.13	4.26
3ccyA01	75.96	Bordetella parapertussisPutative TetR-family transcriptional regulator	1.10.10.60	44	13	55	2.40	4.30
2raeA01	75.46	Rhodococcus jostii RHA1Transcriptional regulator, AcrR family protein	1.10.10.60	43	13	53	2.55	4.79
2qwwC00	75.23	Listeria monocytogenes serotype 4b str. F2365Transcriptional regulator, MarR family	1.10.10.10	130	12	50	2.44	4.88
2ibdA01	74.92	Rhodococcus jostii RHA1Possible transcriptional regulator	1.10.10.60	45	15	55	2.63	4.71
2fd5A01	74.76	Probable transcriptional regulatorPseudomonas aeruginosa	1.10.10.60	48	8	54	2.38	4.36
2bgcH02	72.91	Listeria monocytogenesListeriolysin regulatory protein	1.10.10.10	89	6	70	3.40	4.80

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Domain ATOM Sequence

>pdb|2obpA00
GIDPAIVEVLLVLREAGIENGATPWSLPKIAKRAQLPSVLRRVLTQLQAAGLADVSVEADGRGHASLTQEGAALAAQLFP

BLAST against CATH

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Domain COMBS Sequence

>pdb|2obpA00
GXSDPGNEQNGDGIDPAIVEVLLVLREAGIENGATPWSLPKIAKRAQLPXSVLRRVLTQLQAAGLADVSVEADGRGHASL
TQEGAALAAQLFPDPF

BLAST against CATH

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Domain History Events (12)

Domain assigned by auto on 14 Feb 2008 14:01

Assigning to "1.10.10.10" based on similarity with "2obpB00"