CATH Domain: 2oawA00 XML data for domain: 2oawA00

Molscript image for 2oawA00
2oawA00
PDB coordinates for domain 2oawA00

PDB 2oaw, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.16
2.30.30.40.16.1
2.30.30.40.16.1.3
2.30.30.40.16.1.3.1
2.30.30.40.16.1.3.1.1

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Segment boundaries for domain 2oawA00

Chopping figure for domain 2oawA00
DomainStart PDB ResidueStop PDB Residue
2oawA00 1006 1070

Structural Neighbourhood (70 entries)

There are 70 matching structural neighberhood comparisons for CATH ID 2.30.30.40.16.1.3.1.1 (SIMAX score < 5)

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Displaying entries 1 to 70 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2vwfA00 94.34 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 26 98 0.83 0.84
1ov3A02 92.96 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 24 94 1.06 1.12
1ckaA00 92.87 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 33 96 1.31 1.36
2j6fA00 92.80 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 28 98 1.36 1.38
1yn8A00 92.04 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 26 96 1.40 1.45
2ak5B00 90.95 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 26 89 1.06 1.19
2jteA00 90.92 Mus musculusCD2-associated protein 2.30.30.40 64 28 89 1.08 1.21
2v1rA00 90.25 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 36 83 1.25 1.50
1griA01 90.20 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 37 84 0.91 1.08
1ad5A01 90.18 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 31 88 1.49 1.68
1x6bA01 89.80 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 19 87 1.24 1.42
2vknA00 89.59 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 28 84 1.25 1.47
1jegA00 89.58 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 28 95 1.65 1.74
3ehrB01 89.53 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 24 90 1.84 2.04
2js2A00 89.40 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 33 88 1.72 1.94
2ablA01 89.39 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 29 86 1.52 1.76
1ycsB02 89.11 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 33 87 1.46 1.67
2rqtA00 89.07 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 26 93 1.48 1.58
1tucA00 88.40 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 61 73 73 3.22 4.36
1ng2A02 88.39 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 22 80 1.40 1.73
1wx6A01 88.09 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 26 86 1.59 1.84
2csqA01 87.61 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 22 86 1.72 2.00
1gcqC00 86.92 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 17 82 2.17 2.63
1j3tA00 86.75 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 31 75 1.05 1.39
1awwA00 86.61 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 29 85 1.81 2.13
1uhfA00 86.55 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 29 81 1.66 2.05
1ng2A01 86.38 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 20 75 1.64 2.17
1u3oA01 86.04 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 24 85 1.91 2.23
1spkA00 85.70 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 24 79 1.79 2.26
2epdA00 85.62 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity 2.30.30.40 76 26 75 1.43 1.91
2ke9A00 84.75 Caskin-2Homo sapiens 2.30.30.40 67 22 85 2.25 2.64
3i5rA00 84.53 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 26 70 2.38 3.38
1bb9A00 83.72 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 19 68 2.25 3.28
1sf9A02 83.25 Bacillus subtilisUncharacterized protein yfhH 2.30.30.340 54 9 75 1.84 2.44
2heqA01 83.21 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 7 89 3.01 3.36
1jxmA01 82.97 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 2.30.30.40 80 21 67 2.60 3.85
1igqB00 82.56 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 8 73 2.40 3.26
2rh2A00 82.53 Dihydrofolate reductase type 2Escherichia coli 2.30.30.60 57 8 78 2.50 3.17
2g3rA01 82.44 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 9 82 2.63 3.19
1mhnA00 82.10 Survival motor neuron proteinSurvival motor neuron proteinHomo sapiensProtein binding 2.30.30.140 59 7 81 3.05 3.75
1udlA00 81.44 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 98 33 58 1.52 2.61
1dj7B00 81.40 Ferredoxin-thioredoxin reductase, variable chainProtein bindingSynechocystis sp. PCC 6803 2.30.30.50 73 8 76 3.67 4.78
1ug1A00 81.26 Dynamin-binding proteinHomo sapiensProtein binding 2.30.30.40 92 19 61 1.82 2.94
2aklA02 80.89 Phosphonate and phosphinate metabolismPseudomonas aeruginosaPhosphonoacetate hydrolase [EC:3.11.1.2]Putative uncharacterized protein 2.30.30.40 73 14 76 3.33 4.34
1biaA03 80.64 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 6 78 3.11 3.94
1jb0E00 80.60 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 10 71 2.32 3.27
1uffA00 80.49 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 93 22 61 1.93 3.15
1i1jB00 79.86 Melanoma-derived growth regulatory proteinHomo sapiensExtracellular spaceCell proliferation 2.30.30.40 103 21 55 1.56 2.82
2o2oA00 79.48 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 2.30.30.40 75 24 76 2.49 3.28
1ri9A00 79.31 FYN-binding proteinProtein phosphorylationNucleusHomo sapiensImmune response 2.30.30.40 77 14 71 2.44 3.42
1khcA01 79.03 Protein complex localizationRegulation of gene expression by genetic imprintingDNA (cytosine-5)-methyltransferase 3BChromosome, centromeric regionProtein binding 2.30.30.160 65 8 70 3.24 4.58
2vv5A02 78.68 Escherichia coli O157:H7Small conductance mechanosensitive ion channel, MscS familySmall-conductance mechanosensitive channel 2.30.30.60 50 12 71 2.25 3.13
1m9sA04 78.33 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 86 8 66 2.93 4.42
1m9sA05 78.21 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 78 12 71 3.00 4.18
2k57A00 77.59 Pseudomonas syringae pv. phaseolicola 1448ALipoprotein, putative 2.30.30.100 55 5 75 3.21 4.26
1kq1H00 77.53 RNA degradationHost factor-I proteinSimilar to host factor-1Staphylococcus aureus subsp. aureus Mu50 2.30.30.100 66 8 63 2.42 3.80
1awjA00 77.45 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 33 74 2.42 3.27
2ra2B00 77.37 Salmonella enterica subsp. enterica serovar TyphimuriumPutative lipoprotein 2.30.30.100 55 9 80 3.75 4.65
1u1sA00 76.71 RNA degradationPseudomonas aeruginosaHost factor-I proteinProtein hfq 2.30.30.100 66 3 68 3.30 4.84
1ib8A02 76.36 Hypothetical proteinRibosome maturation factor rimPStreptococcus pneumoniae 2.30.30.180 67 19 71 3.23 4.51
2hqxA01 76.05 Staphylococcal nuclease domain-containing protein 1NucleusGolgi apparatusTranscription cofactor activityHomo sapiens 2.30.30.140 81 8 58 2.60 4.48
1irxA02 75.17 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 4 71 3.43 4.77
1vytA01 74.87 Cardiac muscle contractionRattus norvegicusDilated cardiomyopathyVoltage-gated calcium channel complexCalcium channel, voltage-dependent, beta 3 subunit 2.30.30.40 108 19 52 2.02 3.83
1m5q101 74.87 Pyrobaculum aerophilumSmall nuclear ribonucleoprotein homolog (Sm-like) 2.30.30.100 67 10 62 2.47 3.94
3fb9B00 74.81 Streptococcus pneumoniaePutative uncharacterized protein 2.30.30.100 84 12 52 2.51 4.79
1d3bC00 74.66 SpliceosomeSystemic lupus erythematosusSmall nuclear ribonucleoprotein Sm D3Small nuclear ribonucleoprotein D3Spliceosomal complex 2.30.30.100 71 7 66 2.98 4.50
1pm3A00 74.22 Methanothermobacter thermautotrophicus str. Delta HPutative uncharacterized protein 2.30.30.240 69 12 62 2.62 4.20
1ljoA00 72.80 Archaeoglobus fulgidusSnRNP, putative 2.30.30.100 75 3 64 3.04 4.75
1b34A00 72.41 SpliceosomeSystemic lupus erythematosusSmall nuclear ribonucleoprotein Sm D1RNA bindingProtein binding 2.30.30.100 80 3 53 2.57 4.78
2ch4Y01 71.29 Bacterial chemotaxisTwo-component systemPurine-binding chemotaxis protein CheWThermotoga maritimaChemotaxis protein cheW 2.30.30.40 61 8 73 3.65 4.95
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Displaying entries 1 to 70 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2oawA00
KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVKITVNGKTYERQGFVPAAYVKKLD
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2oawA00
KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVKITVNGKTYERQGFVPAAYVKKLD
BLAST against CATH

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Domain History Events (6)

Domain assigned by auto on 12 Apr 2008 14:19

Assigning to "2.30.30.40" based on similarity with "1bk2A00"

Flow stage update by auto on 12 Apr 2008 14:06

No in_process hits for Domain "2oawA00" ready to be processed

Flow stage update by auto on 12 Apr 2008 14:06

NW result present for Domain "2oawA00"

Flow stage update by auto on 12 Apr 2008 08:09

All required files are present for Domain "2oawA00"

Flow stage update by auto on 11 Apr 2008 09:16

Beginning processing for Domain "2oawA00"

Insertion by auto on 11 Apr 2008 08:08

Final ChopClose added based on similarity with "1bk2A"