CATH Domain: 2o9sA00 XML data for domain: 2o9sA00

Molscript image for 2o9sA00
2o9sA00
PDB coordinates for domain 2o9sA00

PDB 2o9s, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.1
2.30.30.40.1.1
2.30.30.40.1.1.1
2.30.30.40.1.1.1.1
2.30.30.40.1.1.1.1.1

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Segment boundaries for domain 2o9sA00

Chopping figure for domain 2o9sA00
DomainStart PDB ResidueStop PDB Residue
2o9sA00 818 884

Structural Neighbourhood (56 entries)

There are 56 matching structural neighberhood comparisons for CATH ID 2.30.30.40.1.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 56 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1w70A00 91.23 Protein dimerization activityLeukocyte transendothelial migrationNeutrophil cytosolic factor 4CytosolNADPH oxidase complex 2.30.30.40 60 33 89 1.89 2.11
2v1qA00 90.37 Actin cortical patch assemblyMating projection tipIdentical protein bindingNucleusActin filament organization 2.30.30.40 60 15 88 1.18 1.34
2rqtA00 90.25 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 26 89 1.43 1.60
2v1rA00 90.23 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 20 91 1.65 1.81
3i35A00 89.88 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity 2.30.30.40 56 28 83 1.30 1.56
2jteA00 89.85 Mus musculusCD2-associated protein 2.30.30.40 64 25 92 3.52 3.80
2ak5B00 89.79 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 37 95 3.29 3.44
1zlmA00 89.79 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 58 27 86 1.37 1.58
2iimA00 89.77 Phosphoinositide 3-kinase bindingPericentriolar materialCD8 receptor bindingT cell receptor signaling pathwayCD4 receptor binding 2.30.30.40 62 22 92 2.30 2.49
1wyxA00 89.61 RuffleMembrane fractionIntegrin-mediated signaling pathwayB cell receptor signaling pathwayActin filament organization 2.30.30.40 68 25 89 2.46 2.74
1jo8A00 89.58 Actin cortical patch assemblyMating projection tipActin-binding proteinEstablishment of cell polarityProtein localization 2.30.30.40 58 24 86 1.59 1.84
2ablA01 89.54 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 19 94 2.45 2.61
1yn8A00 89.53 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 18 88 1.47 1.67
2vwfA00 89.34 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 30 83 1.32 1.58
1sshA00 89.14 Cellular bud neckIdentical protein bindingActin cortical patch localizationSaccharomyces cerevisiaeMitochondrion 2.30.30.40 60 36 86 2.43 2.81
1ckaA00 89.14 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 25 83 1.16 1.39
2vknA00 89.04 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 27 94 2.55 2.71
3i9qA00 89.01 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 57 24 85 1.28 1.50
3h0hA00 88.97 T cell receptor signaling pathwayLearningPrion diseasesFeeding behaviorTyrosine-protein kinase Fyn 2.30.30.40 63 25 94 2.94 3.13
3eg3A00 88.75 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 62 22 89 2.85 3.18
2j6fA00 88.51 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 29 83 1.30 1.56
1x6bA01 88.48 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 17 92 2.10 2.27
1y0mA00 88.32 Rattus norvegicusCalcium signaling pathwayPhosphatidylinositol signaling systemPathways in cancerPhospholipase C, gamma [EC:3.1.4.11] 2.30.30.40 60 25 89 1.83 2.04
1zuyA00 88.25 Identical protein bindingMating projection tipReceptor-mediated endocytosisActin cortical patch localizationResponse to salt stress 2.30.30.40 58 24 85 1.44 1.69
1ov3A02 87.99 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 20 80 1.08 1.34
1ad5A01 87.96 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 20 92 3.87 4.18
1wx6A01 87.79 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 21 94 2.56 2.72
2csqA01 87.68 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 20 83 1.57 1.88
1ng2A02 87.68 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 16 88 3.19 3.62
1jegA00 87.47 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 33 88 1.59 1.81
1gcqC00 87.22 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 19 89 2.47 2.75
1uhfA00 87.17 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 25 92 4.49 4.84
2epdA00 87.12 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity 2.30.30.40 76 26 85 3.58 4.19
3ehrB01 87.07 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 24 86 2.05 2.37
1griA01 86.95 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 33 71 0.88 1.23
1ycsB02 86.48 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 14 91 3.23 3.55
2js2A00 86.32 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 25 94 3.83 4.07
1awwA00 86.15 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 16 97 4.18 4.31
1j3tA00 86.13 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 26 86 3.95 4.57
1spkA00 86.04 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 22 93 3.69 3.97
2ke9A00 85.36 Caskin-2Homo sapiens 2.30.30.40 67 25 92 4.23 4.57
1bb9A00 85.03 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 16 77 2.35 3.05
3i5rA00 84.39 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 20 80 3.00 3.74
1u3oA01 84.38 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 16 86 2.50 2.89
1ng2A01 83.34 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 11 65 1.26 1.92
1i1jB00 82.66 Melanoma-derived growth regulatory proteinHomo sapiensExtracellular spaceCell proliferation 2.30.30.40 103 14 65 3.08 4.73
1dj7B00 81.72 Ferredoxin-thioredoxin reductase, variable chainProtein bindingSynechocystis sp. PCC 6803 2.30.30.50 73 5 79 3.66 4.61
1g2bA00 81.66 2.30.30.40 59 13 65 3.01 4.58
1jb0E00 81.28 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 8 78 3.41 4.36
2heqA01 80.10 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 9 77 2.75 3.54
2o2oA00 79.48 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 2.30.30.40 75 17 86 3.86 4.45
1vytA01 77.58 Cardiac muscle contractionRattus norvegicusDilated cardiomyopathyVoltage-gated calcium channel complexCalcium channel, voltage-dependent, beta 3 subunit 2.30.30.40 108 13 59 2.91 4.91
1awjA00 77.17 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 16 79 3.25 4.10
2fmmD00 76.84 SpindleChromobox protein 1Chromosome, centromeric regionChromatin bindingEnzyme binding 2.40.50.40 66 9 67 3.30 4.91
1irxA02 75.77 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 6 64 2.79 4.35
3by7E00 75.72 2.30.30.100 74 8 64 3.22 4.96
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Displaying entries 1 to 56 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2o9sA00
GIDPFTGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2o9sA00
GIDPFTGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL
BLAST against CATH

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Domain History Events (10)

Domain assigned by auto on 27 Nov 2007 02:57

Assigning to "2.30.30.40" based on similarity with "2o9vA00"

Flow stage update by auto on 27 Nov 2007 02:56

No in_process hits for Domain "2o9sA00" ready to be processed

Update comment by auto on 27 Nov 2007 02:52

Domain "2o9sA00" hits Domain "2o9vA00" (100% over 100%) which is currently in process

Update comment by auto on 27 Nov 2007 02:48

Domain "2o9sA00" hits Domain "2o31A00" (100% over 100%) which is currently in process

Update comment by auto on 27 Nov 2007 02:37

Domain "2o9sA00" hits Domain "2o2wA00" (100% over 100%) which is currently in process

Flow stage update by auto on 27 Nov 2007 02:25

Domain "2o9sA00" hits Domain "2o2wA00" (100% over 100%) which is currently in process

Flow stage update by auto on 27 Nov 2007 02:25

NW result present for Domain "2o9sA00"

Flow stage update by auto on 24 Nov 2007 14:38

All required files are present for Domain "2o9sA00"

Flow stage update by auto on 24 Nov 2007 02:36

Beginning processing for Domain "2o9sA00"

Insertion by auto on 23 Nov 2007 19:05

Final ChopClose added based on similarity with "2o2wA"