CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00915
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00915
CAH1_HUMAN
Homo sapiens
Carbonic anhydrase 1

PDB Structure

PDB 2NMX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II
Srivastava, D.K., Jude, K.M., Banerjee, A.L., Haldar, M., Manokaran, S., Kooren, J., Mallik, S., Christianson, D.W.
J.Am.Chem.Soc.