CATH Domain: 2j0iA01 XML data for domain: 2j0iA01

Molscript image for 2j0iA01
2j0iA01
PDB coordinates for domain 2j0iA01

PDB 2j0i, Chain A, Domain 1

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.30 2-Layer Sandwich
3.30.200 Phosphorylase Kinase; domain 1
3.30.200.20 Phosphorylase Kinase; domain 1 Gene3D
3.30.200.20.14
3.30.200.20.14.1
3.30.200.20.14.1.1
3.30.200.20.14.1.1.1
3.30.200.20.14.1.1.1.1

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Segment boundaries for domain 2j0iA01

Chopping figure for domain 2j0iA01
DomainStart PDB ResidueStop PDB Residue
2j0iA01 300 397
2j0iA02 398 589

Structural Neighbourhood (47 entries)

There are 47 matching structural neighberhood comparisons for CATH ID 3.30.200.20.14.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 47 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2f57B01 90.75 T cell receptor signaling pathwayP21-activated kinase 7 [EC:2.7.11.1]Protein bindingRenal cell carcinomaErbB signaling pathway 3.30.200.20 106 87 91 1.63 1.78
1u5qA01 88.67 Rattus norvegicusThousand and one amino acid protein kinase [EC:2.7.11.1]Serine/threonine-protein kinase TAO2MAPK signaling pathway 3.30.200.20 96 25 93 1.97 2.10
3c0iA01 87.88 Actin cytoskeletonGuanylate kinase activityPeripheral plasma membrane protein CASKCell adhesionHomo sapiens 3.30.200.20 88 26 84 1.84 2.17
3f3zA01 87.54 Cryptosporidium parvum Iowa IICalcium-dependent protein kinase [EC:2.7.11.1]Calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands 3.30.200.20 81 27 82 1.70 2.06
2weiA01 86.44 Cryptosporidium parvum Iowa IICalmodulin-domain protein kinase 1, putative 3.30.200.20 90 17 86 3.00 3.46
2j51A01 86.13 CytoplasmOocyte meiosisSTE20-like serine/threonine-protein kinasePlasma membraneHomo sapiens 3.30.200.20 90 23 91 3.31 3.60
2h6dA01 86.08 Insulin signaling pathwayHypertrophic cardiomyopathy (HCM)Adipocytokine signaling pathwayRegulation of autophagyMTOR signaling pathway 3.30.200.20 86 19 84 2.80 3.31
2wtkC01 85.63 NucleusSerine/threonine-protein kinase 11Cell cycle arrestProtein bindingSerine/threonine-protein kinase 11 [EC:2.7.11.9] 3.30.200.20 89 20 79 1.70 2.14
2rkuA01 85.60 Polo-like kinase 1 [EC:2.7.11.21]Polo kinase kinase activityProgesterone-mediated oocyte maturationCell proliferationOocyte meiosis 3.30.200.20 89 17 83 2.03 2.43
2acxA02 85.31 G protein-coupled receptor kinase 6Homo sapiensRegulation of G-protein coupled receptor protein signaling pathway 3.30.200.20 91 23 85 1.92 2.24
2clqA01 85.16 Induction of apoptosis by extracellular signalsProtein homodimerization activityMitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]Neurotrophin signaling pathwayATP binding 3.30.200.20 85 21 78 2.11 2.69
2vgpB01 85.14 Serine/threonine-protein kinase 12-AHistone H3-S10 phosphorylationChromosome, centromeric regionProtein bindingChromatin 3.30.200.20 89 20 83 2.24 2.68
2jamA01 85.09 Calcium/calmodulin-dependent protein kinase type 1GHomo sapiensCalcium/calmodulin-dependent protein kinase I [EC:2.7.11.17] 3.30.200.20 75 26 76 1.86 2.43
1tkiA01 84.92 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 3.30.200.20 84 22 83 2.83 3.38
3blhA01 84.76 Transcription elongation from RNA polymerase II promoterCyclin-dependent protein kinase activityRNA polymerase II carboxy-terminal domain kinase activityProtein bindingCell proliferation 3.30.200.20 86 25 83 3.24 3.87
2zv2A01 84.76 Calcium ion bindingRegulation of protein kinase activityPositive regulation of transcriptionMAPKKK cascadeCytoplasm 3.30.200.20 77 23 76 2.25 2.94
1zy4A01 84.70 Eukaryotic translation initiation factor 2alpha kinase activityProtein bindingSerine/threonine-protein kinase GCN2DNA damage checkpointRegulation of translational initiation 3.30.200.20 94 20 84 3.02 3.57
3fhrA01 84.68 Response to stressMAP kinase kinase activityNucleusMitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]MAPK signaling pathway 3.30.200.20 80 18 77 2.26 2.91
2ac3A01 84.47 MAP kinase-interacting serine/threonine-protein kinase 2ATP bindingProtein phosphorylationHomo sapiensProtein serine/threonine kinase activity 3.30.200.20 80 22 79 2.42 3.04
1ob3A01 84.38 Cyclin-dependent kinase [EC:2.7.11.22]Cell division control protein 2 homologPlasmodium falciparum K1 3.30.200.20 83 26 80 3.15 3.91
1x8bA01 84.18 Homo sapiensWee1-like protein kinaseProtein binding 3.30.200.20 84 16 82 3.88 4.69
3hmmA01 84.07 Type II transforming growth factor beta receptor bindingPeptidyl-threonine phosphorylationPositive regulation of cellular component movementPathway-restricted SMAD protein phosphorylationResponse to cholesterol 3.30.200.20 84 23 77 2.06 2.66
1xwsA01 84.07 Transcription factor bindingPositive regulation of cyclin-dependent protein kinase activity involved in G1/SManganese ion bindingNegative regulation of apoptosisProtein binding 3.30.200.20 92 16 83 2.44 2.92
3g51A01 84.02 Progesterone-mediated oocyte maturationNeurotrophin signaling pathwayOocyte meiosisMAPK signaling pathwayLong-term potentiation 3.30.200.20 95 16 85 4.21 4.91
1omwA03 83.89 MembraneG-protein coupled receptor kinase activityNegative regulation of the force of heart contraction by chemical signalChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 3.30.200.20 107 17 76 1.76 2.30
3eqrB01 83.68 Activated CDC42 kinase 1GTPase inhibitor activitySmall GTPase mediated signal transductionHomo sapiensPositive regulation of peptidyl-tyrosine phosphorylation 3.30.200.20 91 24 86 3.42 3.94
1fmkA03 83.67 Epithelial cell signaling in Helicobacter pylori infectionPositive regulation of integrin activationRegulation of bone resorptionProto-oncogene tyrosine-protein kinase SrcErbB signaling pathway 3.30.200.20 86 23 83 2.99 3.57
1lufA01 83.52 Muscle, skeletal receptor tyrosine protein kinaseReceptor clusteringRattus norvegicusResponse to muscle activityMemory 3.30.200.20 97 20 92 3.43 3.69
2r3iA01 83.45 Progesterone-mediated oocyte maturationPathways in cancerSmall cell lung cancerOocyte meiosisProstate cancer 3.30.200.20 76 27 75 2.47 3.27
1qpcA01 83.45 Pericentriolar materialPhosphoinositide 3-kinase bindingCD8 receptor bindingT cell receptor signaling pathwayCD4 receptor binding 3.30.200.20 88 18 88 3.28 3.69
1s9jA01 83.42 Prion diseasesNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 3.30.200.20 86 19 85 4.06 4.74
2dylA01 83.31 Mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]MAP kinase kinase activityNeurotrophin signaling pathwayStress-activated MAPK cascadeT cell receptor signaling pathway 3.30.200.20 91 13 82 2.84 3.44
1o6lA02 83.26 Jak-STAT signaling pathwayRAC-beta serine/threonine-protein kinaseNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathway 3.30.200.20 117 15 70 1.84 2.59
2evaA01 83.22 Positive regulation of T cell cytokine productionActivation of NF-kappaB-inducing kinase activityPositive regulation of interleukin-2 productionMitogen-activated protein kinase kinase kinase 7Protein binding 3.30.200.20 82 24 81 2.96 3.63
1rdqE02 82.96 Calcium signaling pathwayPrion diseasesProtein kinase A [EC:2.7.11.11]Olfactory transductionMesoderm formation 3.30.200.20 124 22 70 1.96 2.79
2rgpA01 82.65 Calcium signaling pathwayPositive regulation of nitric oxide biosynthetic processEpidermal growth factor receptor activityResponse to UV-APositive regulation of cyclin-dependent protein kinase activity involved in G1/S 3.30.200.20 82 14 83 4.15 4.96
2oibA01 82.57 Chagas diseaseNeurotrophin signaling pathwayInterleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]ApoptosisHomo sapiens 3.30.200.20 93 24 82 3.78 4.57
1xbbA01 82.47 T cell receptor complexTyrosine-protein kinase SYKOrgan morphogenesisLeukocyte cell-cell adhesionCell proliferation 3.30.200.20 83 21 82 2.75 3.33
3e64A01 82.36 Jak-STAT signaling pathwayCellular component movementTyrosine-protein kinase JAK2Chemokine signaling pathwayAdipocytokine signaling pathway 3.30.200.20 93 21 88 3.91 4.40
3c4cA01 82.04 Neurotrophin signaling pathwayNon-small cell lung cancerCytoplasmErbB signaling pathwayProtein phosphorylation 3.30.200.20 86 22 83 3.56 4.25
2qkwB01 81.42 Solanum pimpinellifoliumProtein kinaseProtein binding 3.30.200.20 72 20 71 2.04 2.86
2jedB01 81.36 Protein kinase C theta typeProtein bindingT cell receptor signaling pathwayNovel protein kinase C [EC:2.7.11.13]Adipocytokine signaling pathway 3.30.200.20 125 16 65 1.76 2.68
1fvrA01 81.35 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 86 17 85 3.25 3.79
2w5aA01 80.82 NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]Regulation of mitosisSerine/threonine-protein kinase Nek2CentrosomeCentrosome separation 3.30.200.20 64 23 62 2.40 3.86
1ckiA01 80.55 SpindleRattus norvegicusHedgehog signaling pathwaySoluble fractionCircadian rhythm - mammal 3.30.200.20 64 25 63 2.21 3.49
2oo8X01 77.46 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 60 18 57 2.73 4.78
2fstX01 76.66 Cellular component movementMAP kinase kinase activityProtein bindingChemotaxisMitogen-activated protein kinase 14 3.30.200.20 132 18 60 2.74 4.52
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Displaying entries 1 to 47 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2j0iA01
SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVV
EMYNSYLVGDELWVVMEF
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2j0iA01
GSSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVV
IMRDYQHENVVEMYNSYLVGDELWVVMEF
BLAST against CATH

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Domain History Events (6)

Domain assigned by auto on 16 Dec 2006 23:37

Assigning to "3.30.200.20" based on similarity with "2cdzA01"

Flow stage update by auto on 16 Dec 2006 23:32

No in_process hits for Domain "2j0iA01" ready to be processed

Flow stage update by auto on 16 Dec 2006 23:32

NW result present for Domain "2j0iA01"

Flow stage update by auto on 14 Dec 2006 15:49

All required files are present for Domain "2j0iA01"

Flow stage update by auto on 13 Dec 2006 15:37

Beginning processing for Domain "2j0iA01"

Insertion by cuff on 13 Dec 2006 15:24

another batch of choppings