CATH Domain: 2izrA01 XML data for domain: 2izrA01

Molscript image for 2izrA01
2izrA01
PDB coordinates for domain 2izrA01

PDB 2izr, Chain A, Domain 1

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.30 2-Layer Sandwich
3.30.200 Phosphorylase Kinase; domain 1
3.30.200.20 Phosphorylase Kinase; domain 1 Gene3D
3.30.200.20.5
3.30.200.20.5.1
3.30.200.20.5.1.1
3.30.200.20.5.1.1.1
3.30.200.20.5.1.1.1.1

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Segment boundaries for domain 2izrA01

Chopping figure for domain 2izrA01
DomainStart PDB ResidueStop PDB Residue
2izrA01 36 119
2izrA02 120 334

Structural Neighbourhood (60 entries)

There are 60 matching structural neighberhood comparisons for CATH ID 3.30.200.20.5.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 60 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2zv2A01 87.69 Calcium ion bindingRegulation of protein kinase activityPositive regulation of transcriptionMAPKKK cascadeCytoplasm 3.30.200.20 77 23 90 2.26 2.50
1ckiA01 87.15 SpindleRattus norvegicusHedgehog signaling pathwaySoluble fractionCircadian rhythm - mammal 3.30.200.20 64 48 75 2.38 3.14
2wtjA01 86.99 DNA damage response, signal transduction resulting in induction of apoptosisSenescenceSerine/threonine-protein kinase Chk2PML bodyProtein binding 3.30.200.20 79 24 90 2.38 2.63
1tkiA01 86.74 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 3.30.200.20 84 8 96 2.79 2.89
3f3zA01 86.69 Cryptosporidium parvum Iowa IICalcium-dependent protein kinase [EC:2.7.11.1]Calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands 3.30.200.20 81 19 93 2.54 2.70
3hmmA01 86.35 Type II transforming growth factor beta receptor bindingPeptidyl-threonine phosphorylationPositive regulation of cellular component movementPathway-restricted SMAD protein phosphorylationResponse to cholesterol 3.30.200.20 84 16 91 2.44 2.66
1xbbA01 85.87 T cell receptor complexTyrosine-protein kinase SYKOrgan morphogenesisLeukocyte cell-cell adhesionCell proliferation 3.30.200.20 83 18 93 3.80 4.04
2ac3A01 85.86 MAP kinase-interacting serine/threonine-protein kinase 2ATP bindingProtein phosphorylationHomo sapiensProtein serine/threonine kinase activity 3.30.200.20 80 12 91 2.38 2.60
3comB01 85.84 Transcription factor bindingPathways in cancerNon-small cell lung cancerCytoplasmSerine/threonine-protein kinase 4 3.30.200.20 85 20 91 3.06 3.33
2clqA01 85.48 Induction of apoptosis by extracellular signalsProtein homodimerization activityMitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]Neurotrophin signaling pathwayATP binding 3.30.200.20 85 19 90 2.33 2.57
1opjA01 85.42 Protein domain specific bindingNucleusPeptidyl-tyrosine phosphorylationManganese ion bindingMus musculus 3.30.200.20 94 13 86 4.09 4.75
3fhrA01 85.41 Response to stressMAP kinase kinase activityNucleusMitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]MAPK signaling pathway 3.30.200.20 80 15 90 2.80 3.10
2acxA02 85.30 G protein-coupled receptor kinase 6Homo sapiensRegulation of G-protein coupled receptor protein signaling pathway 3.30.200.20 91 16 85 2.31 2.69
3d5vA01 85.29 Danio rerioPolo-like kinase 3.30.200.20 92 16 89 2.43 2.73
1x8bA01 85.05 Homo sapiensWee1-like protein kinaseProtein binding 3.30.200.20 84 14 92 2.79 3.00
2jamA01 85.00 Calcium/calmodulin-dependent protein kinase type 1GHomo sapiensCalcium/calmodulin-dependent protein kinase I [EC:2.7.11.17] 3.30.200.20 75 18 89 2.99 3.35
2i6lA01 85.00 Protein phosphorylationMitogen-activated protein kinase 6Homo sapiensSignal transductionMitogen-activated protein kinase 4/6 [EC:2.7.11.24] 3.30.200.20 91 16 85 2.44 2.85
1z57A01 84.93 Homo sapiensProtein serine/threonine kinase activityNon-membrane spanning protein tyrosine kinase activityDual specificity protein kinase CLK1Cell proliferation 3.30.200.20 94 14 87 2.61 2.99
2rkuA01 84.91 Polo-like kinase 1 [EC:2.7.11.21]Polo kinase kinase activityProgesterone-mediated oocyte maturationCell proliferationOocyte meiosis 3.30.200.20 89 15 88 2.78 3.13
1wakA01 84.83 Regulation of mRNA processingRNA splicingSerine/threonine-protein kinase SRPK1NucleusProtein binding 3.30.200.20 92 16 84 2.50 2.95
2vgpB01 84.78 Serine/threonine-protein kinase 12-AHistone H3-S10 phosphorylationChromosome, centromeric regionProtein bindingChromatin 3.30.200.20 89 16 87 2.25 2.57
2dylA01 84.71 Mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]MAP kinase kinase activityNeurotrophin signaling pathwayStress-activated MAPK cascadeT cell receptor signaling pathway 3.30.200.20 91 8 85 3.72 4.34
2wtkC01 84.70 NucleusSerine/threonine-protein kinase 11Cell cycle arrestProtein bindingSerine/threonine-protein kinase 11 [EC:2.7.11.9] 3.30.200.20 89 15 85 2.79 3.27
3fpqA01 84.47 Rattus norvegicusSerine/threonine-protein kinase WNK1Protein bindingPotassium channel inhibitor activityATP binding 3.30.200.20 91 15 87 3.19 3.63
2weiA01 84.38 Cryptosporidium parvum Iowa IICalmodulin-domain protein kinase 1, putative 3.30.200.20 90 14 92 3.73 4.04
2j51A01 84.38 CytoplasmOocyte meiosisSTE20-like serine/threonine-protein kinasePlasma membraneHomo sapiens 3.30.200.20 90 14 90 3.23 3.59
3blhA01 84.23 Transcription elongation from RNA polymerase II promoterCyclin-dependent protein kinase activityRNA polymerase II carboxy-terminal domain kinase activityProtein bindingCell proliferation 3.30.200.20 86 14 91 3.97 4.32
1t46A01 84.21 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Protein bindingAcute myeloid leukemia 3.30.200.20 96 15 85 4.08 4.78
1uu3A02 84.17 PPAR signaling pathway3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]Peptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorptionNon-small cell lung cancer 3.30.200.20 93 16 82 2.31 2.79
3c0iA01 84.10 Actin cytoskeletonGuanylate kinase activityPeripheral plasma membrane protein CASKCell adhesionHomo sapiens 3.30.200.20 88 16 90 2.99 3.29
2r3iA01 83.86 Progesterone-mediated oocyte maturationPathways in cancerSmall cell lung cancerOocyte meiosisProstate cancer 3.30.200.20 76 25 89 3.45 3.87
2h6dA01 83.82 Insulin signaling pathwayHypertrophic cardiomyopathy (HCM)Adipocytokine signaling pathwayRegulation of autophagyMTOR signaling pathway 3.30.200.20 86 16 93 2.96 3.18
1xwsA01 83.65 Transcription factor bindingPositive regulation of cyclin-dependent protein kinase activity involved in G1/SManganese ion bindingNegative regulation of apoptosisProtein binding 3.30.200.20 92 16 88 2.87 3.26
3f61A01 83.60 Serine/threonine-protein kinase pknBSerine/threonine protein kinase, bacterial [EC:2.7.11.1]Mycobacterium tuberculosis 3.30.200.20 91 18 86 3.06 3.52
1u5qA01 83.41 Rattus norvegicusThousand and one amino acid protein kinase [EC:2.7.11.1]Serine/threonine-protein kinase TAO2MAPK signaling pathway 3.30.200.20 96 19 84 3.33 3.95
2a19C01 83.35 Eukaryotic translation initiation factor 2alpha kinase activityProtein phosphatase type 2A regulator activityInterferon-induced, double-stranded RNA-activated protein kinaseProtein bindingNegative regulation of osteoblast proliferation 3.30.200.20 95 14 84 2.63 3.12
3cc6A01 83.26 Calcium signaling pathwayChemokine signaling pathwayPositive regulation of cell proliferationProtein-tyrosine kinase 2-betaLeukocyte transendothelial migration 3.30.200.20 90 16 88 3.91 4.40
1ob3A01 83.08 Cyclin-dependent kinase [EC:2.7.11.22]Cell division control protein 2 homologPlasmodium falciparum K1 3.30.200.20 83 19 92 3.40 3.66
1q5kA01 83.05 Hedgehog signaling pathwayNeurotrophin signaling pathwayAlzheimer's diseaseT cell receptor signaling pathwayER overload response 3.30.200.20 95 22 82 2.93 3.57
2j0iA01 83.00 Cellular component movementT cell receptor signaling pathwaySignal transductionProtein bindingRenal cell carcinoma 3.30.200.20 98 15 82 3.48 4.21
1zy4A01 82.82 Eukaryotic translation initiation factor 2alpha kinase activityProtein bindingSerine/threonine-protein kinase GCN2DNA damage checkpointRegulation of translational initiation 3.30.200.20 94 15 87 2.99 3.43
2f57B01 82.58 T cell receptor signaling pathwayP21-activated kinase 7 [EC:2.7.11.1]Protein bindingRenal cell carcinomaErbB signaling pathway 3.30.200.20 106 16 75 3.47 4.60
1fmkA03 82.41 Epithelial cell signaling in Helicobacter pylori infectionPositive regulation of integrin activationRegulation of bone resorptionProto-oncogene tyrosine-protein kinase SrcErbB signaling pathway 3.30.200.20 86 19 93 4.40 4.73
1nd4A01 82.37 Aminoglycoside 3'-phosphotransferaseKlebsiella pneumoniae 3.30.200.20 86 9 91 3.83 4.17
1kobA01 82.29 Aplysia californicaTwitchin-like protein 3.30.200.20 109 13 75 3.11 4.13
2w5aA01 82.22 NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]Regulation of mitosisSerine/threonine-protein kinase Nek2CentrosomeCentrosome separation 3.30.200.20 64 14 73 2.71 3.69
2qkwB01 82.07 Solanum pimpinellifoliumProtein kinaseProtein binding 3.30.200.20 72 12 81 2.53 3.09
2bkkA01 82.07 Aminoglycoside 3'-phosphotransferaseAminoglycoside 3'-phosphotransferase [EC:2.7.1.95]Enterococcus faecalis 3.30.200.20 90 10 87 3.48 3.96
1lufA01 81.88 Muscle, skeletal receptor tyrosine protein kinaseReceptor clusteringRattus norvegicusResponse to muscle activityMemory 3.30.200.20 97 14 83 3.98 4.77
2oibA01 81.28 Chagas diseaseNeurotrophin signaling pathwayInterleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]ApoptosisHomo sapiens 3.30.200.20 93 15 79 3.27 4.11
3k3iA01 81.24 Cellular component movementMAP kinase kinase activityProtein bindingChemotaxisMitogen-activated protein kinase 14 3.30.200.20 92 14 86 3.03 3.48
2b1pA01 81.02 MAP kinase kinase activityMitogen-activated protein kinase 10Homo sapiensProtein binding 3.30.200.20 101 16 80 2.67 3.33
2jiiA01 80.88 Serine/threonine-protein kinase VRK3Homo sapiensProtein binding 3.30.200.20 110 16 69 2.60 3.76
3csvA01 80.83 Aminoglycoside phosphotransferaseRuegeria sp. TM1040 3.30.200.20 81 6 86 3.55 4.09
1o6lA02 80.57 Jak-STAT signaling pathwayRAC-beta serine/threonine-protein kinaseNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathway 3.30.200.20 117 15 66 2.48 3.72
2oo8X01 80.33 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 60 16 69 2.35 3.36
1omwA03 80.31 MembraneG-protein coupled receptor kinase activityNegative regulation of the force of heart contraction by chemical signalChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 3.30.200.20 107 18 73 2.58 3.49
2ppqA01 78.53 Glycine, serine and threonine metabolismMetabolic pathwaysAgrobacterium tumefaciens str. C58Homoserine kinaseHomoserine kinase type II [EC:2.7.1.39] 3.30.200.20 93 13 80 3.78 4.69
2q83B01 78.35 Bacillus subtilisSpore coat protein ISpore coat protein I 3.30.200.20 97 9 77 3.28 4.24
2jedB01 77.74 Protein kinase C theta typeProtein bindingT cell receptor signaling pathwayNovel protein kinase C [EC:2.7.11.13]Adipocytokine signaling pathway 3.30.200.20 125 16 64 2.99 4.61
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Displaying entries 1 to 60 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2izrA01
VLMVGPNFRVGKKIGCNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVL
ELL
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2izrA01
SMGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYN
AMVLELL
BLAST against CATH

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Domain History Events (6)

Domain assigned by auto on 22 Dec 2006 23:35

Assigning to "3.30.200.20" based on similarity with "2chlA01"

Flow stage update by auto on 22 Dec 2006 23:31

No in_process hits for Domain "2izrA01" ready to be processed

Flow stage update by auto on 22 Dec 2006 23:31

NW result present for Domain "2izrA01"

Flow stage update by auto on 17 Dec 2006 15:26

All required files are present for Domain "2izrA01"

Flow stage update by auto on 16 Dec 2006 23:32

Beginning processing for Domain "2izrA01"

Insertion by auto on 16 Dec 2006 23:25

Final ChopClose added based on similarity with "2iztA"