CATH Domain: 2iimA00 XML data for domain: 2iimA00

Molscript image for 2iimA00
2iimA00
PDB coordinates for domain 2iimA00

PDB 2iim, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.2
2.30.30.40.2.1
2.30.30.40.2.1.1
2.30.30.40.2.1.1.1
2.30.30.40.2.1.1.1.1

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Segment boundaries for domain 2iimA00

Chopping figure for domain 2iimA00
DomainStart PDB ResidueStop PDB Residue
2iimA00 58 119

Structural Neighbourhood (58 entries)

There are 58 matching structural neighberhood comparisons for CATH ID 2.30.30.40.2.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 58 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
3h0hA00 93.88 T cell receptor signaling pathwayLearningPrion diseasesFeeding behaviorTyrosine-protein kinase Fyn 2.30.30.40 63 48 95 1.83 1.92
2v1qA00 93.28 Actin cortical patch assemblyMating projection tipIdentical protein bindingNucleusActin filament organization 2.30.30.40 60 20 93 0.89 0.95
1ckaA00 92.51 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 35 88 1.24 1.40
1ad5A01 92.48 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 51 92 1.14 1.24
1jo8A00 92.29 Actin cortical patch assemblyMating projection tipActin-binding proteinEstablishment of cell polarityProtein localization 2.30.30.40 58 24 88 0.77 0.87
1zlmA00 92.14 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 58 37 91 1.82 1.98
1sshA00 92.06 Cellular bud neckIdentical protein bindingActin cortical patch localizationSaccharomyces cerevisiaeMitochondrion 2.30.30.40 60 33 91 2.03 2.21
2vwfA00 91.92 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 35 87 0.72 0.83
2ak5B00 91.90 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 25 93 1.87 1.99
1ov3A02 91.76 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 16 85 0.97 1.13
2vknA00 91.74 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 29 89 2.30 2.57
3eg3A00 91.63 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 62 30 93 2.60 2.78
3i35A00 91.59 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity 2.30.30.40 56 21 87 0.86 0.99
3i9qA00 91.42 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 57 31 88 1.31 1.48
1w70A00 91.34 Protein dimerization activityLeukocyte transendothelial migrationNeutrophil cytosolic factor 4CytosolNADPH oxidase complex 2.30.30.40 60 20 93 2.53 2.70
1yn8A00 91.24 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 25 91 1.81 1.97
2v1rA00 91.06 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 25 89 1.64 1.83
2jteA00 90.80 Mus musculusCD2-associated protein 2.30.30.40 64 25 93 3.33 3.55
1x6bA01 90.62 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 14 90 1.21 1.34
1zuyA00 90.56 Identical protein bindingMating projection tipReceptor-mediated endocytosisActin cortical patch localizationResponse to salt stress 2.30.30.40 58 18 90 1.31 1.45
1y0mA00 90.49 Rattus norvegicusCalcium signaling pathwayPhosphatidylinositol signaling systemPathways in cancerPhospholipase C, gamma [EC:3.1.4.11] 2.30.30.40 60 25 91 1.18 1.28
2rqtA00 90.43 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 21 91 1.49 1.62
1wyxA00 90.22 RuffleMembrane fractionIntegrin-mediated signaling pathwayB cell receptor signaling pathwayActin filament organization 2.30.30.40 68 25 82 1.33 1.61
2j6fA00 90.18 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 26 87 1.18 1.35
2ablA01 90.11 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 35 90 2.69 2.96
2js2A00 89.88 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 29 96 4.06 4.19
1wx6A01 89.86 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 30 87 1.72 1.96
1jegA00 89.62 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 33 91 1.78 1.94
1ycsB02 89.43 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 27 93 2.98 3.18
1ng2A02 89.42 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 14 86 3.38 3.90
1gcqC00 89.31 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 16 86 1.96 2.25
3ehrB01 89.08 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 27 91 2.12 2.31
2csqA01 88.98 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 19 84 1.51 1.78
1griA01 88.80 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 33 77 0.75 0.97
1uhfA00 87.63 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 29 86 2.33 2.68
1spkA00 87.61 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 19 86 2.17 2.52
1awwA00 87.23 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 41 91 3.03 3.33
1j3tA00 87.06 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 25 79 1.64 2.06
2epdA00 85.88 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity 2.30.30.40 76 24 78 2.71 3.43
2ke9A00 85.71 Caskin-2Homo sapiens 2.30.30.40 67 22 86 2.22 2.56
1ng2A01 85.56 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 20 69 1.68 2.42
3i5rA00 85.46 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 20 74 2.15 2.90
1bb9A00 85.36 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 19 74 3.04 4.07
1g2bA00 84.25 2.30.30.40 59 22 66 1.24 1.88
1u3oA01 84.21 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 19 91 3.29 3.58
2hbwA01 83.85 Anabaena variabilis ATCC 29413NLP/P60 2.30.30.40 72 11 77 2.69 3.46
1jxmA01 83.19 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 2.30.30.40 80 24 65 2.28 3.51
1igqB00 82.44 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 10 75 2.85 3.76
2heqA01 82.33 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 11 82 2.74 3.33
2g3rA01 81.80 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 11 79 3.53 4.47
1ug1A00 81.13 Dynamin-binding proteinHomo sapiensProtein binding 2.30.30.40 92 14 65 2.04 3.13
1udlA00 80.87 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 98 24 60 2.64 4.39
1uffA00 80.42 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 93 22 62 2.15 3.45
1jb0E00 79.73 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 6 75 3.38 4.49
2o2oA00 78.76 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 2.30.30.40 75 20 80 3.42 4.28
1uebA02 77.94 Thermus thermophilus HB8Elongation factor EF-PElongation factor P 2.40.50.140 63 12 60 2.81 4.66
1biaA03 77.89 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 6 74 3.19 4.30
1irxA02 76.48 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 20 66 2.56 3.87
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Displaying entries 1 to 58 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2iimA00
GSPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKA
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2iimA00
GSPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKA
BLAST against CATH

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Domain History Events (6)

Domain assigned by auto on 29 Jul 2007 11:01

Assigning to "2.30.30.40" based on similarity with "1h92A00"

Flow stage update by auto on 29 Jul 2007 10:56

No in_process hits for Domain "2iimA00" ready to be processed

Flow stage update by auto on 29 Jul 2007 10:56

NW result present for Domain "2iimA00"

Flow stage update by auto on 14 Jul 2007 06:02

All required files are present for Domain "2iimA00"

Flow stage update by auto on 13 Jul 2007 18:42

Beginning processing for Domain "2iimA00"

Insertion by auto on 13 Jul 2007 12:56

Final ChopClose added based on similarity with "1h92A"