CATH Domain: 2i5fA00 XML data for domain: 2i5fA00

Molscript image for 2i5fA00
2i5fA00
PDB coordinates for domain 2i5fA00

PDB 2i5f, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.9
2.30.29.30.9.1
2.30.29.30.9.1.1
2.30.29.30.9.1.1.1
2.30.29.30.9.1.1.1.1

[top]
Segment boundaries for domain 2i5fA00

Chopping figure for domain 2i5fA00
DomainStart PDB ResidueStop PDB Residue
2i5fA00 241 347

Structural Neighbourhood (30 entries)

There are 30 matching structural neighberhood comparisons for CATH ID 2.30.29.30.9.1.1.1.1 (SIMAX score < 5)

[1]
Displaying entries 1 to 30 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1faoA00 88.78 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 29 90 2.58 2.87
1u5dA00 87.06 Positive regulation of transcription from RNA polymerase II promoterPlasma membraneT cell receptor signaling pathwayAntigen bindingCytoplasm 2.30.29.30 108 27 83 2.02 2.42
3cxbB00 86.91 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 19 85 1.99 2.33
2dn6A00 86.08 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens 2.30.29.30 115 34 79 2.33 2.94
1qqgA01 86.08 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 25 80 1.68 2.08
1btnA00 85.73 Mus musculusSpectrin beta chain, brain 1SMAD protein import into nucleusCuticular platePlasma membrane 2.30.29.30 106 16 79 2.06 2.60
1v89A00 85.70 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 33 77 2.30 2.95
1zsqA01 84.10 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 6 86 3.02 3.51
1ef1A03 83.43 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 7 86 2.50 2.90
1dynA00 83.20 GTPase activityReceptor-mediated endocytosisHomo sapiensDynamin-1Protein binding 2.30.29.30 113 16 78 2.30 2.92
2he7A03 82.82 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 2.30.29.30 95 8 84 2.52 2.99
1plsA00 82.71 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 28 81 2.84 3.49
1txdA02 82.70 Rho guanine nucleotide exchange factor 12Homo sapiensRegulation of actin cytoskeletonG-protein-coupled receptor bindingG-protein coupled receptor protein signaling pathway 2.30.29.30 121 18 75 2.48 3.30
1t77A01 82.65 Lipopolysaccharide-responsive and beige-like anchor proteinHomo sapiensProtein binding 2.30.29.40 105 7 80 3.61 4.51
1ddwA00 82.43 DendriteType 5 metabotropic glutamate receptor bindingRattus norvegicusResponse to cocaineResponse to stress 2.30.29.30 109 6 77 2.57 3.30
1evhA00 82.18 LamellipodiumFocal adhesionSH3 domain bindingStress fiberActin polymerization or depolymerization 2.30.29.30 111 7 79 2.63 3.32
2dhjA00 81.43 Rho GTPase-activating protein 21Homo sapiens 2.30.29.30 125 25 72 3.27 4.49
1dbhA02 81.01 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 19 67 2.28 3.37
2rgnB02 80.99 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 16 71 2.39 3.34
1mixA02 80.87 Talin-1Focal adhesionFocal adhesionGallus gallusTalin 2.30.29.30 93 9 90 3.13 3.47
1v88A00 80.80 Oxysterol-binding protein-related protein 8Homo sapiens 2.30.29.30 130 17 70 3.21 4.59
1kz7C02 80.71 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 19 67 2.29 3.41
2coaA01 80.55 Homo sapiensSerine/threonine-protein kinase D2 2.30.29.30 118 18 73 2.73 3.70
1w1hD00 80.47 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]PPAR signaling pathwayPeptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorptionNon-small cell lung cancer 2.30.29.30 137 20 62 2.03 3.23
1btkA00 79.84 Induction of apoptosis by extracellular signalsPhosphatidylinositol-3,4,5-trisphosphate bindingIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.29.30 160 23 55 1.85 3.33
1qqgA02 79.23 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 8 83 3.43 4.10
1rrpB00 78.57 E3 SUMO-protein ligase RanBP2Ran GTPase bindingNuclear poreProtein import into nucleusHomo sapiens 2.30.29.30 134 6 68 2.99 4.36
1pfjA00 78.48 Positive regulation of transcription from RNA polymerase II promoterGeneral RNA polymerase II transcription factor activityGeneral transcription factor IIH subunit 1Nucleotide excision repairRegulation of cyclin-dependent protein kinase activity 2.30.29.30 108 5 80 3.16 3.92
1xr0B01 78.31 Fibroblast growth factor receptor substrate 2Membrane fractionIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase adaptor activityNeurotrophin signaling pathway 2.30.29.30 91 12 89 3.64 4.08
1q67A01 78.28 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding 2.30.29.30 140 9 62 2.70 4.30
[1]
Displaying entries 1 to 30 (page 1 of 1)


[top]
Domain ATOM Sequence 

>pdb|2i5fA00
FTGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESEENLFEIITADEVHYFLQ
AATPKERTEWIKAIQMASR
BLAST against CATH

[top]
Domain COMBS Sequence 

>pdb|2i5fA00
GSFTGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEEENLFEII
TADEVHYFLQAATPKERTEWIKAIQMASR
BLAST against CATH

[top]
Domain History Events (6)

Domain assigned by auto on 25 Nov 2007 18:30

Assigning to "2.30.29.30" based on similarity with "1zm0A00"

Flow stage update by auto on 25 Nov 2007 18:19

No in_process hits for Domain "2i5fA00" ready to be processed

Flow stage update by auto on 25 Nov 2007 18:19

NW result present for Domain "2i5fA00"

Flow stage update by auto on 24 Nov 2007 14:37

All required files are present for Domain "2i5fA00"

Flow stage update by auto on 23 Nov 2007 14:01

Beginning processing for Domain "2i5fA00"

Insertion by auto on 23 Nov 2007 10:12

Final ChopClose added based on similarity with "1zm0A"