CATH Domain: 2hxsA00 XML data for domain: 2hxsA00

Molscript image for 2hxsA00
2hxsA00
PDB coordinates for domain 2hxsA00

PDB 2hxs, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.40 3-Layer(aba) Sandwich
3.40.50 Rossmann fold
3.40.50.300 P-loop containing nucleotide triphosphate hydrolases Gene3D
3.40.50.300.13
3.40.50.300.13.1
3.40.50.300.13.1.1
3.40.50.300.13.1.1.1
3.40.50.300.13.1.1.1.1

Segment boundaries for domain 2hxsA00

Chopping figure for domain 2hxsA00
DomainStart PDB ResidueStop PDB Residue
2hxsA00 7 184

Structural Neighbourhood (22 entries)

There are 22 matching structural neighberhood comparisons for CATH ID 3.40.50.300.13.1.1.1.1 (SIMAX score < 5)

Displaying entries 1 to 22 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1z2aA00 88.70 Mus musculusRegulation of smoothened signaling pathwaySpinal cord dorsal/ventral patterningRas-related protein Rab-23Negative regulation of proteolysis 3.40.50.300 164 30 92 3.88 4.21
2ce2X00 88.67 Neurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathwayTight junction 3.40.50.300 166 28 92 4.24 4.57
1wmsA00 88.13 Ras-related protein Rab-9ALysosomeGTP bindingProtein bindingGDP binding 3.40.50.300 170 27 91 3.92 4.30
3c5cB00 88.05 Ras-like protein family member 12Homo sapiensRas-like, family 12 3.40.50.300 164 20 92 3.82 4.15
1r2qA00 88.00 Ras-related protein Rab-5AGTP bindingEndocytosisGDP bindingGTPase activity 3.40.50.300 170 30 91 4.36 4.75
1z0jA00 87.72 Ras-related protein Rab-22AMus musculusGTPase activityGTP bindingProtein binding 3.40.50.300 169 23 91 4.20 4.58
3cbqA00 87.30 Rad and Gem related GTP binding protein 2GTP-binding protein REM 2Homo sapiens 3.40.50.300 169 21 88 2.13 2.42
1xtqA00 87.16 Insulin signaling pathwayMTOR signaling pathwayGTP-binding protein RhebGTPase activityGTP binding 3.40.50.300 169 27 92 4.16 4.48
1mh1A00 85.98 MAPK signaling pathwayNatural killer cell mediated cytotoxicityVEGF signaling pathwayFocal adhesionToll-like receptor signaling pathway 3.40.50.300 183 25 85 4.26 5.00
2x19A00 85.88 Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Nucleus organizationNucleusNucleocytoplasmic transportProtein binding 3.40.50.300 172 24 91 4.41 4.83
1m7bA00 85.81 Actin cytoskeleton organizationRho-related GTP-binding protein RhoEGTPase activityGTP bindingCell adhesion 3.40.50.300 179 20 84 4.00 4.74
1mkyA02 82.87 Thermotoga maritimaGTP-binding proteinGTP-binding protein engA 3.40.50.300 149 15 84 3.80 4.48
2h57B00 82.27 ADP-ribosylation factor-like 6ADP-ribosylation factor-like protein 6Homo sapiens 3.40.50.300 164 11 90 3.63 4.02
1mkyA01 82.19 Thermotoga maritimaGTP-binding proteinGTP-binding protein engA 3.40.50.300 153 15 85 4.21 4.92
1byuB00 81.23 GTP-binding nuclear protein RanCanis lupus familiaris 3.40.50.300 215 23 72 2.40 3.31
3cx8A01 79.34 Rho protein signal transductionIn utero embryonic developmentGTPase activityPlatelet activationRegulation of cell migration 3.40.50.300 193 17 76 3.71 4.84
1udxA02 78.38 Thermus thermophilus HB8GTP-binding proteinGTPase obg 3.40.50.300 174 15 85 4.07 4.79
2dbyA01 77.35 Thermus thermophilus HB8GTP-binding protein 3.40.50.300 170 13 73 3.23 4.39
2qvgA00 75.09 Two component response regulator[EC:2.7.3.-]Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3.40.50.2300 126 12 71 3.58 4.99
2qr3A00 73.82 Bacteroides fragilisTwo-component system response regulator 3.40.50.2300 119 14 71 3.42 4.77
1jr2A01 73.13 Uroporphyrinogen-III synthase [EC:4.2.1.75]Metabolic pathwaysPorphyrin and chlorophyll metabolismUroporphyrinogen-III synthase activityHomo sapiens 3.40.50.10090 120 15 66 3.19 4.83
1a04A01 72.47 Two-component systemTwo-component system, NarL family, nitrate/nitrite response regulator NarLProtein bindingEscherichia coli K-12Nitrate/nitrite response regulator protein narL 3.40.50.2300 124 6 72 3.55 4.87
Displaying entries 1 to 22 (page 1 of 1)


Domain ATOM Sequence

>pdb|2hxsA00
GSHMRQLKIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQIWDIGGQTIGGKMLDKYIYGA
QGVLLVYDITNYQSFENLEDWYTVVKKVSEESETQPLVALVGNKIDLEHMRTIKPEKHLRFCQENGFSSHFVSAKTGDSV
FLCFQKVAAEILGIKLNK    

Domain COMBS Sequence

>pdb|2hxsA00
GSHMRQLKIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQIWDIGGQTIGGKMLDKYIYGA
QGVLLVYDITNYQSFENLEDWYTVVKKVSEESETQPLVALVGNKIDLEHMRTIKPEKHLRFCQENGFSSHFVSAKTGDSV
FLCFQKVAAEILGIKLNK    

Domain History Events (6)

Domain assigned by auto on 25 Nov 2007 14:41

Assigning to "3.40.50.300" based on similarity with "1d5cA00"

Flow stage update by auto on 25 Nov 2007 14:27

No in_process hits for Domain "2hxsA00" ready to be processed

Flow stage update by auto on 25 Nov 2007 14:27

NW result present for Domain "2hxsA00"

Flow stage update by auto on 24 Nov 2007 14:37

All required files are present for Domain "2hxsA00"

Flow stage update by auto on 23 Nov 2007 14:01

Beginning processing for Domain "2hxsA00"

Insertion by auto on 23 Nov 2007 10:10

Final ChopClose added based on similarity with "1d5cA"