CATH Domain: 2hbwA01 XML data for domain: 2hbwA01

Molscript image for 2hbwA01
2hbwA01
PDB coordinates for domain 2hbwA01

PDB 2hbw, Chain A, Domain 1

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.9
2.30.30.40.9.1
2.30.30.40.9.1.1
2.30.30.40.9.1.1.1
2.30.30.40.9.1.1.1.1

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Segment boundaries for domain 2hbwA01

Chopping figure for domain 2hbwA01
DomainStart PDB ResidueStop PDB Residue
2hbwA01 14 86
2hbwA02 87 234

Structural Neighbourhood (49 entries)

There are 49 matching structural neighberhood comparisons for CATH ID 2.30.30.40.9.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 49 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
3ehrB01 84.45 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 6 80 2.44 3.03
3h0hA00 83.03 T cell receptor signaling pathwayLearningPrion diseasesFeeding behaviorTyrosine-protein kinase Fyn 2.30.30.40 63 12 80 2.78 3.45
1zuyA00 82.97 Identical protein bindingMating projection tipReceptor-mediated endocytosisActin cortical patch localizationResponse to salt stress 2.30.30.40 58 12 79 3.05 3.85
1ckaA00 82.97 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 8 76 2.75 3.60
2v1rA00 82.65 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 7 79 2.92 3.69
1jo8A00 82.60 Actin cortical patch assemblyMating projection tipActin-binding proteinEstablishment of cell polarityProtein localization 2.30.30.40 58 5 79 2.80 3.54
1wx6A01 82.33 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 7 83 4.15 4.98
1spkA00 82.31 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 6 88 3.52 3.96
1gcqC00 82.19 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 10 86 3.78 4.39
2csqA01 82.10 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 7 83 4.09 4.91
1yn8A00 81.73 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 6 80 2.90 3.60
2vwfA00 81.43 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 10 77 3.06 3.93
1ng2A02 81.42 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 11 75 2.77 3.69
1ov3A02 81.31 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 12 75 2.74 3.65
2ablA01 81.26 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 12 77 3.41 4.38
1jegA00 81.16 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 6 79 2.92 3.69
2ak5B00 80.95 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 10 80 3.25 4.03
3i35A00 80.92 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity 2.30.30.40 56 10 76 2.86 3.74
2rqtA00 80.88 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 6 81 3.20 3.91
2js2A00 80.84 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 4 79 3.51 4.43
1ycsB02 80.82 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 10 76 2.69 3.52
1w70A00 80.81 Protein dimerization activityLeukocyte transendothelial migrationNeutrophil cytosolic factor 4CytosolNADPH oxidase complex 2.30.30.40 60 8 76 2.93 3.84
2jteA00 80.50 Mus musculusCD2-associated protein 2.30.30.40 64 7 77 2.91 3.74
1sshA00 80.17 Cellular bud neckIdentical protein bindingActin cortical patch localizationSaccharomyces cerevisiaeMitochondrion 2.30.30.40 60 8 76 3.49 4.57
1sf9A02 80.12 Bacillus subtilisUncharacterized protein yfhH 2.30.30.340 54 7 61 2.12 3.47
1j3tA00 80.10 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 9 86 3.95 4.57
3i9qA00 79.95 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 57 10 77 3.05 3.92
1awwA00 79.95 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 5 81 3.47 4.23
1ib8A02 79.61 Hypothetical proteinRibosome maturation factor rimPStreptococcus pneumoniae 2.30.30.180 67 1 75 2.71 3.61
1bb9A00 79.46 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 11 69 2.87 4.11
1griA01 79.41 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 12 66 2.66 3.99
2heqA01 79.32 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 12 69 2.52 3.63
2p84A02 79.01 ORF041Staphylococcus phage 37 2.30.30.290 71 7 68 2.33 3.42
2j6fA00 78.84 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 12 76 3.36 4.40
3be3A00 78.62 Bordetella bronchisepticaPutative uncharacterized protein 2.30.30.320 75 9 69 2.81 4.05
1mhnA00 78.56 Survival motor neuron proteinSurvival motor neuron proteinHomo sapiensProtein binding 2.30.30.140 59 6 69 3.05 4.39
1igqB00 78.30 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 10 65 3.05 4.67
1khcA01 78.07 Protein complex localizationRegulation of gene expression by genetic imprintingDNA (cytosine-5)-methyltransferase 3BChromosome, centromeric regionProtein binding 2.30.30.160 65 9 65 2.82 4.32
1m9sA05 77.18 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 78 12 78 2.86 3.66
1jb0E00 76.94 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 7 68 2.94 4.32
1ov3A01 76.78 GTP bindingSoluble fractionCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 55 7 62 3.01 4.82
2rh2A00 76.70 Dihydrofolate reductase type 2Escherichia coli 2.30.30.60 57 5 62 2.43 3.89
1biaA03 76.24 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 4 61 2.66 4.35
1ng2A01 76.14 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 9 58 2.82 4.83
2g3rA01 76.08 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 5 68 3.25 4.78
2vv5A02 75.85 Escherichia coli O157:H7Small conductance mechanosensitive ion channel, MscS familySmall-conductance mechanosensitive channel 2.30.30.60 50 10 59 2.73 4.57
1kq1H00 75.73 RNA degradationHost factor-I proteinSimilar to host factor-1Staphylococcus aureus subsp. aureus Mu50 2.30.30.100 66 3 62 2.68 4.29
3fb9B00 75.58 Streptococcus pneumoniaePutative uncharacterized protein 2.30.30.100 84 6 57 2.50 4.38
1awjA00 74.89 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 6 74 3.23 4.36
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Displaying entries 1 to 49 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2hbwA01
SGEYQCLAALNLYDSPECTSLATQAAVGRHLQVTSNQQGAAVEVCLCEDDYPGWLSLGDLGLLKPATVLYQAK
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2hbwA01
GXLSNLESSIQSPKSGEYQCLAALNLYDSPECTSLATQAAVGRHLQVTSNQQGAAVEVCLCEDDYPGWLSLGDLGLLKPA
TVLYQAK
BLAST against CATH

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Domain History Events (12)

Domain assigned by auto on 04 Feb 2008 14:36

Assigning to "2.30.30.40" based on similarity with "2evrA01"

Flow stage update by auto on 04 Feb 2008 14:33

No in_process hits for Domain "2hbwA01" ready to be processed

Update comment by auto on 04 Feb 2008 14:31

Domain "2hbwA01" hits Domain "2fg0B01" (75.6756756756757% over 85.0574712643678%) which is currently in process

Update comment by auto on 04 Feb 2008 14:24

Domain "2hbwA01" hits Domain "2fg0A01" (75.6756756756757% over 85.0574712643678%) which is currently in process

Update comment by auto on 03 Sep 2007 20:09

Domain "2hbwA01" hits Domain "2evrA01" (75.6756756756757% over 85.0574712643678%) which is currently in process

Update comment by auto on 03 Sep 2007 11:16

Domain "2hbwA01" hits Domain "2evrA01" (75.6756756756757% over 85.0574712643678%) which is currently in process

Update comment by auto on 26 Aug 2007 22:06

Domain "2hbwA01" hits Domain "2evrA01" (75.6756756756757% over 85.0574712643678%) which is currently in process

Flow stage update by auto on 26 Aug 2007 22:05

Domain "2hbwA01" hits Domain "2evrA01" (75.6756756756757% over 85.0574712643678%) which is currently in process

Flow stage update by auto on 26 Aug 2007 22:05

NW result present for Domain "2hbwA01"

Flow stage update by auto on 19 Aug 2007 10:12

All required files are present for Domain "2hbwA01"

Flow stage update by auto on 18 Aug 2007 14:31

Beginning processing for Domain "2hbwA01"

Insertion by auto on 18 Aug 2007 14:10

Final ChopClose added based on similarity with "2evrA"