CATH Domain: 2h5cA02

2h5cA02

PDB 2h5c, Chain A, Domain 2

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.10	Thrombin, subunit H
2.40.10.10	Trypsin-like serine proteases	Gene3D
2.40.10.10.2
2.40.10.10.2.1
2.40.10.10.2.1.1
2.40.10.10.2.1.1.1
2.40.10.10.2.1.1.1.1

Structure
Sequence
History

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Segment boundaries for domain 2h5cA02

Domain	Start PDB Residue	Stop PDB Residue
2h5cA01	16	119
2h5cA01	231	243
2h5cA02	120	230

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (13 entries)

There are 13 matching structural neighberhood comparisons for CATH ID 2.40.10.10.2.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
2qa9E02	89.92	Streptomyces griseusStreptogrisin-B	2.40.10.10	94	36	86	1.55	1.79
2qf3B02	84.31	Protease degSProtein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	2.40.10.10	103	14	76	2.52	3.30
1y8tB02	84.19	Two-component systemPutative serine protease PepD [EC:3.4.21.-]PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE) (MTB32B)Mycobacterium tuberculosis	2.40.10.10	111	16	78	2.38	3.04
1lcyA02	81.57	Serine-type endopeptidase activityHtrA serine peptidase 2 [EC:3.4.21.108]Endoplasmic reticulum membraneParkinson's diseaseNucleus	2.40.10.10	84	15	71	3.19	4.45
2j92A02	81.49	Foot-and-mouth disease virus (strain A10-61)Genome polyprotein	2.40.10.10	109	11	76	2.78	3.65
2halA02	81.12	Human hepatitis A virus Hu/Australia/HM175/1976Genome polyprotein	2.40.10.10	103	10	76	2.61	3.42
2hrvA02	79.33	Genome polyproteinHuman rhinovirus 2	2.40.10.10	95	12	75	2.95	3.91
1lvoA02	78.47	Replicase polyprotein 1abPorcine transmissible gastroenteritis coronavirus strain Purdue	2.40.10.10	88	4	66	2.81	4.20
2o8mA02	77.92	Genome polyproteinHepatitis C virus subtype 1a	2.40.10.10	87	11	65	2.66	4.09
1befA02	75.80		2.40.10.10	85	15	65	2.85	4.38
2h5cA01	75.16	Lysobacter enzymogenesAlpha-lytic protease	2.40.10.10	85	4	60	2.86	4.74
3fanA02	75.10	Porcine reproductive and respiratory syndrome virusNon-structural protein	2.40.10.10	69	24	56	2.37	4.19
1svpA02	74.56	Sindbis virusStructural polyprotein	2.40.10.10	86	10	61	2.44	3.98

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Domain ATOM Sequence

>pdb|2h5cA02
PRVANGSSFVTVRGSTEAAVGAAVCRSGRTTGYQCGTITAKNVTANYAEGAVRGLTQGNACMGRGDSGGSWITSAGQAQG
VMSGGNVQSNGNNCGIPASQRSSLFER

BLAST against CATH

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Domain COMBS Sequence

>pdb|2h5cA02
PRVANGSSFVTVRGSTEAAVGAAVCRSGRTTGYQCGTITAKNVTANYAEGAVRGLTQGNACMGRGDSGGSWITSAGQAQG
VMSGGNVQSNGNNCGIPASQRSSLFER

BLAST against CATH

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Domain History Events (11)

Domain assigned by auto on 01 Nov 2006 18:36

Assigning to "2.40.10.10" based on similarity with "1ssxA02"