CATH Domain: 2fwhA00

2fwhA00

PDB 2fwh, Chain A, Domain 0

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.30	Glutaredoxin
3.40.30.10	Glutaredoxin	Gene3D
3.40.30.10.1
3.40.30.10.1.1
3.40.30.10.1.1.1
3.40.30.10.1.1.1.1
3.40.30.10.1.1.1.1.1

Structure
Sequence
History

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Segment boundaries for domain 2fwhA00

Domain	Start PDB Residue	Stop PDB Residue
2fwhA00	428	544

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (38 entries)

There are 38 matching structural neighberhood comparisons for CATH ID 3.40.30.10.1.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
1gh2A00	86.35	CytoplasmHomo sapiensThioredoxin-like protein 1Disulfide oxidoreductase activity	3.40.30.10	107	14	89	2.24	2.50
2vimA00	85.98	Fasciola hepaticaThioredoxin (TRX)	3.40.30.10	104	19	88	2.11	2.40
2i4aA00	85.98		3.40.30.10	107	14	90	2.31	2.55
1w4vA00	85.94	Thioredoxin, mitochondrialHomo sapiensThioredoxin 1	3.40.30.10	110	20	91	2.73	2.99
2pu9C00	85.50	Thioredoxin F-type, chloroplasticSpinacia oleraceaProtein binding	3.40.30.10	111	18	90	2.54	2.80
1thxA00	85.26	Nostoc sp. PCC 7120Thioredoxin-2	3.40.30.10	108	14	89	2.62	2.92
2j23A00	84.93	Malassezia sympodialisThioredoxin	3.40.30.10	115	20	90	2.64	2.91
1r26A00	84.72	Trypanosoma brucei bruceiThioredoxin	3.40.30.10	113	16	88	2.25	2.53
2e0qA00	84.35	Sulfolobus tokodaii140aa long hypothetical thioredoxinThioredoxin 1	3.40.30.10	104	15	86	2.39	2.77
2kucA00	84.22	Bacteroides thetaiotaomicronPutative disulphide-isomerase	3.40.30.10	121	24	90	2.45	2.72
2b5eA01	83.10	Protein disulfide isomerase activityProtein disulfide oxidoreductase activityProtein bindingProtein foldingEndoplasmic reticulum lumen	3.40.30.10	119	17	90	2.98	3.28
3gnjA00	82.44	Desulfitobacterium hafniense DCB-2Thioredoxin domain protein	3.40.30.10	107	14	88	2.71	3.08
1v98A00	82.42	Thermus thermophilus HB8Thioredoxin 2 [EC:1.8.1.8]Thioredoxin	3.40.30.10	92	18	75	2.72	3.62
1wouA00	82.10	Thioredoxin domain-containing protein 17Tumor necrosis factor-mediated signaling pathwayProtein bindingCytosolProtein-disulfide reductase activity	3.40.30.10	119	14	89	3.04	3.38
1senA00	81.87	Protein-disulfide reductase (glutathione) [EC:1.8.4.2]Homo sapiensGlutathione metabolismThioredoxin domain-containing protein 12	3.40.30.10	134	20	77	2.32	2.99
2dizA00	81.57	Anti-apoptosisHomo sapiensThioredoxin domain-containing protein 5	3.40.30.10	117	13	87	2.98	3.42
2c0gA01	81.54	Protein targeting to GolgiRegulation of multicellular organism growthProtein homodimerization activityEmbryo development ending in birth or egg hatchingDrosophila melanogaster	3.40.30.10	122	11	90	2.96	3.28
1zmaA00	81.01	Bacterocin transport accessory proteinStreptococcus pneumoniae R6	3.40.30.10	116	11	89	3.22	3.59
3gixA00	80.75	Thioredoxin-like protein 4BHomo sapiens	3.40.30.10	133	12	78	2.60	3.33
1qgvA00	80.72	SpliceosomeSpliceosomal complexU5 snRNP protein, DIM1 familyHomo sapiensProtein binding	3.40.30.10	130	13	84	3.13	3.70
1a8yA02	80.23	Calsequestrin-1Oryctolagus cuniculus	3.40.30.10	102	10	83	3.18	3.80
3f9uA00	80.14	Bacteroides fragilis NCTC 9343Putative exported cytochrome C biogenesis-related protein	3.40.30.10	139	16	78	2.62	3.34
2f51A00	79.99	Trichomonas vaginalisThioredoxin 1Thioredoxin	3.40.30.10	101	13	81	2.84	3.50
1mekA00	79.96	Cell surfaceER-Golgi intermediate compartmentProtein disulfide isomerase activityProtein bindingPeptidyl-proline hydroxylation to 4-hydroxy-L-proline	3.40.30.10	120	20	90	3.45	3.83
1bjxA00	79.77	Cell surfaceProtein disulfide isomerase activityER-Golgi intermediate compartmentProtein bindingPeptidyl-proline hydroxylation to 4-hydroxy-L-proline	3.40.30.10	110	6	82	3.18	3.84
3fk8A00	79.68	Disulphide isomeraseXylella fastidiosa Temecula1	3.40.30.10	120	14	86	3.72	4.29
2trcP01	79.27	PhosducinRattus norvegicus	3.40.30.10	131	8	77	3.28	4.25
1kngA00	78.44	Cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbEBradyrhizobium japonicumThiol:disulfide interchange protein cycY	3.40.30.10	144	13	68	3.19	4.69
1a8yA01	78.34	Calsequestrin-1Oryctolagus cuniculus	3.40.30.10	124	11	83	3.65	4.35
2b5eA04	77.88	Endoplasmic reticulum lumenProtein disulfide oxidoreductase activityProtein disulfide isomerase activityProlyl 4-hydroxylase, beta polypeptide [EC:5.3.4.1]Saccharomyces cerevisiae	3.40.30.10	140	16	73	3.12	4.24
2in3A01	77.72	Nitrosomonas europaeaPutative protein-disulfide isomerasePutative uncharacterized protein	3.40.30.10	78	16	62	2.16	3.46
1sjiA03	76.95	Canis lupus familiarisCalsequestrin-2	3.40.30.10	123	6	91	3.92	4.30
1ttzA00	76.85	Xanthomonas campestris pv. campestrisPutative uncharacterized protein	3.40.30.10	74	16	62	2.89	4.63
2qsiA01	76.14	Putative hydrogenase expression/formation protein hupGHydrogenase-1 operon protein HyaERhodopseudomonas palustris	3.40.30.10	82	12	68	2.80	4.09
1g7eA00	75.79	Rattus norvegicusEndoplasmic reticulum lumenEndoplasmic reticulum protein 29Transport vesicleEndoplasmic reticulum resident protein 29	3.40.30.10	122	7	88	4.17	4.71
2okaA00	74.94	Pseudomonas aeruginosaSelenoprotein W-related proteinPutative uncharacterized protein	3.40.30.10	84	17	59	2.75	4.60
2p0gB00	74.57	Vibrio choleraeSelenoprotein W-related proteinSelenoprotein W-related protein	3.40.30.10	79	12	58	2.86	4.85
1iloA00	73.52	Methanothermobacter thermautotrophicus str. Delta HConserved protein	3.40.30.10	77	7	61	2.47	4.01

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Domain ATOM Sequence

>pdb|2fwhA00
HLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNV
LGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDR

BLAST against CATH

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Domain COMBS Sequence

>pdb|2fwhA00
ATHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQD
VALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDRQPHHHHHH

BLAST against CATH

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Domain History Events (13)

Domain assigned by auto on 02 Nov 2006 03:42

Assigning to "3.40.30.10" based on similarity with "2fweA00"

Flow stage update by auto on 02 Nov 2006 03:17

No in_process hits for Domain "2fwhA00" ready to be processed

Update comment by auto on 01 Nov 2006 21:57

Domain "2fwhA00" hits Domain "2fwgA00" (100% over 100%) which is currently in process