CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Disintegrin and metalloproteinase domain-containing protein 17

Enzyme Information

3.4.24.86
ADAM 17 endopeptidase.
based on mapping to UniProt P78536
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.

UniProtKB Entries (1)

P78536
ADA17_HUMAN
Homo sapiens
Disintegrin and metalloproteinase domain-containing protein 17

PDB Structure

PDB 2FV9
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies.
Ingram, R.N., Orth, P., Strickland, C.L., Le, H.V., Madison, V., Beyer, B.M.
Protein Eng.Des.Sel.