CATH Domain: 2ekpA00 XML data for domain: 2ekpA00

Molscript image for 2ekpA00
2ekpA00
PDB coordinates for domain 2ekpA00

PDB 2ekp, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.40 3-Layer(aba) Sandwich
3.40.50 Rossmann fold
3.40.50.720 NAD(P)-binding Rossmann-like Domain Gene3D
3.40.50.720.16
3.40.50.720.16.1
3.40.50.720.16.1.1
3.40.50.720.16.1.1.1
3.40.50.720.16.1.1.1.1

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Segment boundaries for domain 2ekpA00

Chopping figure for domain 2ekpA00
DomainStart PDB ResidueStop PDB Residue
2ekpA00 2 239

Structural Neighbourhood (42 entries)

There are 42 matching structural neighberhood comparisons for CATH ID 3.40.50.720.16.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 42 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2zatA00 90.02 PeroxisomeDehydrogenase/reductase SDR family member 4 [EC:1.1.-.-]Sus scrofaDehydrogenase/reductase SDR family member 4Retinol metabolism 3.40.50.720 251 33 94 1.79 1.90
1ydeN00 89.62 17-beta-hydroxysteroid dehydrogenase 14Testosterone 17-beta-dehydrogenase (NADP+) activityEstradiol 17-beta-dehydrogenase activitySteroid catabolic processHomo sapiens 3.40.50.720 240 29 95 1.64 1.72
1zk4A00 89.46 Lactobacillus brevisR-specific alcohol dehydrogenase 3.40.50.720 244 27 93 2.03 2.16
2ew8B00 89.42 Ethylbenzene degradation(S)-1-Phenylethanol dehydrogenaseAromatoleum aromaticum EbN1 3.40.50.720 228 32 91 1.55 1.70
1cydA00 89.39 Carbonyl reductase (NADPH) activityArachidonic acid metabolismProtein tetramerizationCarbonyl reductase [NADPH] 2Metabolic pathways 3.40.50.720 242 27 95 1.47 1.53
1geeA00 89.17 Bacillus megateriumGlucose 1-dehydrogenase 3.40.50.720 261 28 90 1.80 1.99
2ag5C00 89.13 NAD or NADH bindingMetabolic pathwaysButanoate metabolismCytoplasm3-hydroxybutyrate dehydrogenase type 2 3.40.50.720 244 27 94 1.84 1.94
1iy8A00 89.12 Leifsonia aquaticaLevodione reductase 3.40.50.720 258 28 91 1.78 1.95
1fmcA00 89.02 7-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.159]7-alpha-hydroxysteroid dehydrogenaseEscherichia coli K-12Cytosol 3.40.50.720 255 27 91 1.87 2.04
2rhcA00 88.95 Putative ketoacyl reductaseBiosynthesis of type II polyketide backboneStreptomyces coelicolorKetoacyl reductase [EC:1.3.1.-] 3.40.50.720 257 34 91 1.81 1.97
2ztuB00 88.70 Pseudomonas fragiD(-)-3-hydroxybutyrate dehydrogenase 3.40.50.720 207 34 86 1.47 1.70
1spxA00 88.70 Caenorhabditis elegansProtein D1054.8, confirmed by transcript evidenceDetermination of adult lifespan 3.40.50.720 237 29 92 3.14 3.40
3grpD00 88.54 3-oxoacyl-(Acyl carrierprotein) reductaseBartonella henselae3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]Fatty acid biosynthesisBiosynthesis of unsaturated fatty acids 3.40.50.720 209 34 82 1.33 1.61
1h5qA00 88.51 NADP-dependent mannitol dehydrogenaseAgaricus bisporus 3.40.50.720 260 31 90 1.73 1.91
2o23A00 88.45 3-hydroxyacyl-CoA dehydrogenase type-2Lipid metabolic process7-alpha-hydroxysteroid dehydrogenase activityPlasma membraneHomo sapiens 3.40.50.720 241 25 91 2.13 2.33
3iccA00 88.21 Bacillus anthracisOxidoreductase, short-chain dehydrogenase/reductase family 3.40.50.720 248 29 91 1.58 1.73
1zemA00 88.19 Gluconobacter oxydansXylitol dehydrogenase 3.40.50.720 260 26 89 1.67 1.87
2z1nA00 88.15 Aeropyrum pernix3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]Putative dehydrogenaseFatty acid biosynthesisBiosynthesis of unsaturated fatty acids 3.40.50.720 237 32 92 1.85 2.00
2x9gD00 88.10 Pteridine reductaseTrypanosoma brucei brucei 3.40.50.720 248 27 91 2.03 2.21
1gz6B01 87.22 PeroxisomeRattus norvegicusPrimary bile acid biosynthesis3(or 17)beta-hydroxysteroid dehydrogenase activityPeroxisomal multifunctional enzyme type 2 3.40.50.720 219 26 85 2.00 2.33
1ja9A00 87.21 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]Fatty acid biosynthesis1,3,6,8-tetrahydroxynaphthalene reductaseBiosynthesis of unsaturated fatty acidsMagnaporthe grisea 3.40.50.720 259 28 87 1.91 2.18
1yxmC00 87.19 PeroxisomePeroxisomal trans-2-enoyl-CoA reductasePeroxisomal trans-2-enoyl-CoA reductase [EC:1.3.1.38]Homo sapiensBiosynthesis of unsaturated fatty acids 3.40.50.720 263 29 78 1.80 2.29
1hxhA00 87.08 3-beta-hydroxysteroid dehydrogenaseComamonas testosteroni 3.40.50.720 253 25 92 3.06 3.29
2p91C00 86.87 Enoyl-[acyl-carrier-protein] reductase [NADH]Aquifex aeolicus 3.40.50.720 228 24 87 1.81 2.06
2dknB00 86.84 3-alpha-hydroxysteroid dehydrogenasePseudomonas sp. B-0831 3.40.50.720 226 24 81 2.67 3.28
1bdbA00 86.72 Biphenyl degradationCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [EC:1.3.1.56]Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenaseBurkholderia xenovorans LB400Metabolic pathways 3.40.50.720 267 24 85 2.08 2.44
2qq5A00 86.59 NucleusGolgi apparatusEndoplasmic reticulumHomo sapiensDehydrogenase/reductase SDR family member 1 3.40.50.720 238 23 90 3.43 3.78
1xg5B00 86.30 Dehydrogenase/reductase SDR family member 11Homo sapiens 3.40.50.720 241 22 90 2.51 2.79
1zmtA00 86.03 3.40.50.720 252 24 91 2.28 2.50
1xq1A00 85.60 Arabidopsis thalianaTropinone reductase homolog At1g07440Response to cadmium ion 3.40.50.720 218 27 80 2.07 2.58
1xu9C00 85.18 Aldosterone-regulated sodium reabsorptionCorticosteroid 11-beta-dehydrogenase isozyme 1Homo sapiensSteroid hormone biosynthesis11beta-hydroxysteroid dehydrogenase [EC:1.1.1.146] 3.40.50.720 258 21 83 2.02 2.41
2a4kB01 84.97 3.40.50.720 196 34 78 2.66 3.39
3gemD00 84.76 Pseudomonas syringae pv. phaseolicola 1448A[EC:1.-.-.-]Oxidoreductase, short chain dehydrogenase/reductase family 3.40.50.720 209 22 86 2.38 2.75
1oaaA00 84.55 DeathRegulation of multicellular organism growthProtein homodimerization activitySepiapterin reductasePteridine metabolic process 3.40.50.720 259 21 87 2.69 3.07
2h7iA00 84.32 Enoyl-[acyl-carrier-protein] reductase [NADH]Enoyl ACP reductase [EC:1.3.1.9]Mycobacterium tuberculosis 3.40.50.720 268 20 86 2.14 2.46
2oosB00 84.00 Enoyl-ACP reductasePlasmodium falciparum 3.40.50.720 283 20 83 2.76 3.32
1sbyA00 83.80 Scaptodrosophila lebanonensisAlcohol dehydrogenase 3.40.50.720 252 18 85 3.39 3.96
3d7lA00 83.50 Listeria innocuaLin1944 protein 3.40.50.720 196 19 81 2.15 2.62
1jtvA00 82.99 CytoplasmEstradiol 17-beta-dehydrogenase 1Homo sapiens 3.40.50.720 278 23 81 4.00 4.92
1ooeA00 82.28 Dihydropteridine reductase [EC:1.5.1.34]Caenorhabditis elegansProtein T03F6.1, confirmed by transcript evidenceFolate biosynthesisMetabolic pathways 3.40.50.720 235 15 91 3.66 4.01
1n7hA02 81.98 Amino sugar and nucleotide sugar metabolismGDPmannose 4,6-dehydratase [EC:4.2.1.47]Fructose and mannose metabolismCytosolMetabolic pathways 3.40.50.720 231 13 84 3.75 4.44
1ek6A02 80.82 Amino sugar and nucleotide sugar metabolismGalactose metabolismUDP-glucose 4-epimeraseProtein homodimerization activityUDP-glucose 4-epimerase activity 3.40.50.720 218 13 79 2.77 3.49
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Displaying entries 1 to 42 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2ekpA00
ERKALVTGGSRGIGRAIAEALVARGYRVAIASRNPEEAAQSLGAVPLPTDLEKDDPKGLVKRALEALGGLHVLVHAAAVN
VRKPALELSYEEWRRVLYLHLDVAFLLAQAAAPHMAEAGWGRVLFIGSVTTFTAGGPVPIPAYTTAKTALLGLTRALAKE
WARLGIRVNLLCPGYVETEFTLPLRQNPELYEPITARIPMGRWARPEEIARVAAVLCGDEAEYLTGQAVAVDGGFLAY
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2ekpA00
MERKALVTGGSRGIGRAIAEALVARGYRVAIASRNPEEAAQSLGAVPLPTDLEKDDPKGLVKRALEALGGLHVLVHAAAV
NVRKPALELSYEEWRRVLYLHLDVAFLLAQAAAPHMAEAGWGRVLFIGSVTTFTAGGPVPIPAYTTAKTALLGLTRALAK
EWARLGIRVNLLCPGYVETEFTLPLRQNPELYEPITARIPMGRWARPEEIARVAAVLCGDEAEYLTGQAVAVDGGFLAY
BLAST against CATH

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Domain History Events (11)

Domain assigned by auto on 05 Apr 2008 17:32

Assigning to "3.40.50.720" based on similarity with "2ekqD00"

Flow stage update by auto on 05 Apr 2008 17:32

No in_process hits for Domain "2ekpA00" ready to be processed

Update comment by auto on 05 Apr 2008 17:30

Domain "2ekpA00" hits Domain "2ekqA00" (100% over 100%) which is currently in process

Update comment by auto on 05 Apr 2008 17:28

Domain "2ekpA00" hits Domain "2ekqC00" (100% over 100%) which is currently in process

Update comment by auto on 05 Apr 2008 17:24

Domain "2ekpA00" hits Domain "2ekqB00" (100% over 100%) which is currently in process

Update comment by auto on 05 Apr 2008 14:18

Domain "2ekpA00" hits Domain "2ekqD00" (100% over 100%) which is currently in process

Flow stage update by auto on 05 Apr 2008 14:07

Domain "2ekpA00" hits Domain "2ekqD00" (100% over 100%) which is currently in process

Flow stage update by auto on 05 Apr 2008 14:07

NW result present for Domain "2ekpA00"

Flow stage update by auto on 05 Apr 2008 08:22

All required files are present for Domain "2ekpA00"

Flow stage update by auto on 04 Apr 2008 12:01

Beginning processing for Domain "2ekpA00"

Insertion by auto on 04 Apr 2008 11:10

Final ChopClose added based on similarity with "1x1eA"